早产儿与足月儿新生儿化脓性脑膜炎临床特征比较  

Comparison of Clinical Features of Neonatal Purulent Meningitis in Preterm and Term Infants

作　　者：刘淑可 李晓春[1] 程贤高[1] LIU Shu-ke;LI Xiao-chun;CHENG Xian-gao(Department of Pediatrics,Anqing Hospital,Anhui Medical University,Anqing 246000,Anhui,China)

机构地区：[1]安徽医科大学附属安庆医院儿科,安徽安庆246000

出　　处：《医学信息》2020年第3期108-110,共3页Journal of Medical Information

摘　　要：目的比较早产儿与足月儿新生儿化脓性脑膜炎的临床特征。方法回顾性分析2014年4月~2019年4月我院确诊的82例新生儿化脓性脑膜炎患儿的临床资料,依据胎龄分为早产儿组(<37周)14例和足月儿组(37~42周)68例,比较两组化脓性脑膜炎的临床特征、白细胞计数、C-反应蛋白、血降钙素原、病原菌检查。结果足月儿组发热发生率高于早产儿组,黄疸发生率低于早产儿组,差异有统计学意义(P<0.05);两组拒乳、反应迟钝、惊厥、呼吸道症状发生率比较,差异无统计学意义(P>0.05);足月儿组C-反应蛋白水平高于早产儿组[(38.04±45.35)mg/L vs(12.13±12.62)mg/L],差异有统计学意义(P<0.05);两组白细胞计数比较,差异无统计学意义(P>0.05)。足月儿组葡萄糖含量高于早产儿组,蛋白含量低于早产儿组[(2.61±0.50)mmol/L vs(2.21±0.63)mmol/L]、[(1266.71±523.36)mmol/L vs(1838.64±664.43)mmol/L],差异有统计学意义(P<0.05)。脑脊液培养中早产儿组仅培养出1例大肠埃希菌,足月儿组共培养出6例,其中以凝固酶隐形葡萄球菌为主;血培养中早产儿组与足月儿组均以凝固酶阴性葡萄球菌为主。结论新生儿化脓性脑膜炎以发热,拒乳、反应迟钝、惊厥等为常见临床表现,其中足月主要以发热为主,早产儿以黄疸为主,且C-反应蛋白水平、葡萄糖含量较低,蛋白含量较高。临床上可根据患儿的临床表现,并结合脑脊液、病原菌检查结果进行诊断,使患儿得到早期治疗。Objective To compare the clinical characteristics of purulent meningitis in preterm infants and term infants.Methods The clinical data of 82 neonatal purulent meningitis children diagnosed in our hospital from April 2014 to April 2019 were retrospectively analyzed.According to the gestational age,14 cases were born into preterm infants(<37 weeks)and term infants.68 patients in the group(37~42 weeks).The clinical characteristics,white blood cell count,C-reactive protein,procalcitonin,and pathogenic bacteria were compared between the two groups.Results The incidence of fever in the term infant group was higher than that in the preterm infant group,and the incidence of jaundice was lower than that in the preterm infant group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of milk rejection,slow response,convulsions,and respiratory symptoms between the two groups(P>0.05);the C-reactive protein level in the term infant group was higher than that in the preterm infant group[(38.04±45.35)mg/L vs(12.13±12.62)mg/L],the difference was statistically significant(P<0.05);There was no significant difference in white blood cell count between the two groups(P>0.05).The glucose content of the term infant group was higher than that of the preterm infant group,and the protein content was lower than that of the preterm infant group,[(2.61±0.50)mmol/L vs(2.21±0.63)mmol/L],[(1266.71±523.36)mmol/L vs(1838.64±664.43)mmol/L],the difference was statistically significant(P<0.05).In the cerebrospinal fluid culture,only 1 case of Escherichia coli was cultured in the preterm infant group,and 6 cases were cultured in the term infant group,of which staphylococcus staphylococcus was the main one;in the blood culture,both the preterm infant group and the term infant group were coagulated.Mainly enzyme-negative staphylococci.Conclusion Fever,menopausal meningitis,fever rejection,sluggish response,and convulsions are common clinical manifestations in neonates.Fever is predominant in te

关 键 词：化脓性脑膜炎 C-反应蛋白 病原菌 

分 类 号：R722[医药卫生—儿科]