Diagnostic Accuracy of Three-Dimensional Whole-Heart Magnetic Resonance Angiography to Detect Coronary Artery Disease with Invasive Coronary Angiography as a Reference:A Meta-Analysis  

作　　者：Shiqin Yu Chen Cui Minjie Lu Shihua Zhao 

机构地区：[1]Department of Cardiac MR,Fuwai Hospital,National Center for Cardiovascular Diseases of China,Chinese Academy of Medical Sciences and Peking Union Medical College,No.167 Beilishi Road,100037 Beijing,People’s Republic of China

出　　处：《Cardiovascular Innovations and Applications》2020年第1期173-184,共12页心血管创新与应用（英文）

基　　金：The study was supported by a major international(regional)joint research project of the National Natural Science Foundation of China(no.81620108015).

摘　　要：Objective:We aimed to evaluate the diagnostic performance of three-dimensional whole-heart magnetic resonance coronary angiography(MRCA)in detecting coronary artery disease(CAD)with invasive coronary angiography as the reference standard.Methods:We searched PubMed and Embase for studies evaluating the diagnostic performance of three-dimensional whole-heart MRCA for the diagnosis of CAD with invasive coronary angiography as the reference standard.The bivariate mixed-effects regression model was applied to synthesize available data.The clinical utility of whole-heart MRCA was calculated by the posttest probability based on Bayes’s theorem.Results:Eighteen studies were included,of which 16 provided data at the artery level.Patient-based analysis revealed a pooled sensitivity of 0.90(95%confi dence interval[CI]0.87–0.93)and specifi city of 0.79(95%CI 0.73–0.84),while the pooled estimates were 0.86(95%CI 0.82–0.89)and 0.89(95%CI 0.84–0.92),respectively,at the artery level.The areas under the summary receiver operating characteristic curve were 0.93(95%CI 0.90–0.95)and 0.92(95%CI 0.90–0.94)at the patient and artery levels,respectively.With a pretest probability of 50%,the patients’posttest probabilities of CAD were 81%for positive results and 11%for negative results.Conclusions:Whole-heart MRCA can be an alternative noninvasive method for diagnosis and assessment of CAD.

关 键 词：magnetic resonance CORONARY ANGIOGRAPHY whole-heart CORONARY artery disease INVASIVE CORONARY ANGIOGRAPHY 

分 类 号：R54[医药卫生—心血管疾病]