二氢卟吩铁溶液的基本性质初探  

Preliminary Study on the Basic Properties of Iron Chlorin Solution

作　　者：陈洋 王乐天 李文玎 任勇 Chen Yang;Wang Letian;Li Wending;Ren Yong(School of Life Sciences,Nanjing Normal University,Key Laboratory for Supramolecular Medicinal Materials and Applications,Nanjing 210023,China;Nanjing Better Biology Co.,Ltd.,Nanjing 211161,China)

机构地区：[1]南京师范大学生命科学学院,江苏省医药超分子材料及应用重点实验室,江苏南京210023 [2]南京百特生物工程有限公司,江苏南京211161

出　　处：《南京师大学报（自然科学版）》2020年第1期143-148,共6页Journal of Nanjing Normal University(Natural Science Edition)

基　　金：江苏省科技发展计划项目(BM2007205).

摘　　要：研究二氢卟吩铁溶液基本性质,为产品制剂改进提供技术支持.高效液相测定二氢卟吩铁溶液稳定性;光度法测定溶解度、分析溶液状态;计算机模拟分子结构,计算各种缔合方式的体系能量.结果表明:二氢卟吩铁难溶或基本不溶于常规溶剂,固体长期放置后溶解度亦有明显下降;其甲醇及碱溶液较稳定,而乙醇中不稳定;此外,溶液中二氢卟吩铁存在明显分子缔合,其中甲醇、甲-乙醇(1∶1)及碱溶液中主要为二分子缔合,乙醇中主要为四分子缔合;分子模拟计算发现,二氢卟吩铁分子具有较高缔合能,其中键角能和范德华力为主要作用力.研究表明,二氢卟吩铁分子的缔合作用可能是影响产品溶解性、稳定性的重要原因.The basic properties of iron chlorin solution,were studied to provide technical support for the improvement of product preparation.Iron chlorin solution stability was determined by HPLC.The solubility and solution state were determined by spectrophotometry.The molecular structure is simulated by computer to calculate the system energy of various association modes.The results showed that iron chlorin was indissolvable or insoluble in conventional solvents,and the solubility of solid was decreased after long-term placement.The methanol and alkali solutions were stable,while the ethanol was unstable.In addition,there was obvious molecular association of iron chlorin in the solution,in which there were mainly two molecular associations in methanol,methanol-ethanol(1∶1)and alkali solution,and there were mainly four molecular associations in ethanol.Molecular simulation showed that iron chlorin had higher association energy,in which bond angle energy and Van der Waals force were the main forces.The study shows that the association of iron chlorin may be an important reason that affects the solubility and stability of product.

关 键 词：二氢卟吩铁 分子缔合 稳定性 溶解性 

分 类 号：S482.8[农业科学—农药学]