基于超声靶向微泡破坏技术的纳米给药系统的研究进展  

Research progress of nano drug delivery system based on ultrasoundtargeted microbubble destruction technology

作　　者：周厚妊 张月[1] 辛莹 李诗慧 刘小奇 刘治军[1] ZHOU Houren;ZHANG Yue;XIN Ying;LI Shihui;LIU Xiaoqi;LIU Zhijun(Department of Ultrasound,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院超声科,沈阳市110004

出　　处：《临床超声医学杂志》2020年第3期208-211,共4页Journal of Clinical Ultrasound in Medicine

基　　金：国家自然科学基金项目(81801712)。

摘　　要：纳米给药系统是治疗多种疾病,尤其是肿瘤的一种极具应用潜力的方法。然而,目前其药物输送效率仍难以满足靶向治疗的需要。超声靶向微泡破坏(UTMD)技术作为一种安全的物理靶向方法,可以增强组织渗透性和细胞膜通透性,进而提高纳米给药系统的药物递送效率。本文就UTMD介导的纳米给药系统的研究进行综述。Nano-drug delivery system is a potential method to treat many diseases,especially tumors.However,drug delivery efficiency does not meet the needs of targeted therapy.Ultrasonic-targeted microbubble destruction(UTMD),as a safe physical targeting method,can enhance tissue and cell membrance permeability,improving the drug delivery efficiency of nanodrug delivery system.This article reviews the research of UTMD-mediated nano drug delivery systems.

关 键 词：超声靶向微泡破坏技术 靶向性 纳米给药系统 肿瘤 

分 类 号：R445.1[医药卫生—影像医学与核医学]