水凝胶再生修复退变椎间盘的研究进展  

Research progress of hydrogel used for regeneration of nucleus pulposus in intervertebral disc degeneration

作　　者：石坤 黄勇[1] 黄雷震 王竞成 王珏翰 丰干钧[1] 刘立岷[1] 宋跃明[1] SHI Kun;HUANG Yong;HUANG Leizhen;WANG Jingcheng;WANG Yuhan;FENG Ganjun;LIU Limin;SONG Yueming(Departmen of Orthopedics,West China Hospital,Sichuan University,Chengdu Sichuan,610041,P.R.China)

机构地区：[1]四川大学华西医院骨科,成都610041

出　　处：《中国修复重建外科杂志》2020年第3期275-284,共10页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金面上项目(81572160、81772397、81871772);四川省科学技术厅项目(2017SZ0046、2017SZDZX0021)。

摘　　要：目的总结生物材料水凝胶治疗椎间盘退变的研究进展,探讨水凝胶再生修复退变椎间盘的临床应用潜能。方法广泛查阅国内外有关水凝胶修复退变椎间盘尤其是髓核组织的研究文献,并进行总结和分析。结果水凝胶与髓核组织具有相似特性,在退变椎间盘再生修复中扮演重要角色,主要可体现在人工髓核假体、以水凝胶为载体的细胞治疗、非细胞治疗和组织工程修复。结论水凝胶作为生物材料广泛应用于椎间盘的再生修复治疗,为治疗椎间盘退变提供了新方向。Objective To summarize the research progress of hydrogels for the regeneration and repair of degenerative intervertebral disc and to investigate the potential of hydrogels in clinical application.Methods The related literature about the role of hydrogels in intervertebral disc degeneration especially for nucleus pulposus was reviewed and analyzed.Results Hydrogels share similar properties with nucleus pulposus,and it plays an important role in the regeneration and repair of degenerative intervertebral disc,which can be mainly applied in nucleus pulposus prosthesis,hydrogel-based cell therapy,non-cellular therapy,and tissue engineering repair.Conclusion Hydrogels are widely used in the regeneration and repair of intervertebral disc,which provides a potential treatment for intervertebral disc degeneration.

关 键 词：水凝胶 椎间盘退变 髓核 再生 修复 

分 类 号：R681.53[医药卫生—骨科学]