合成生物学领域的基础研究与技术创新关联分析  

Correlation Analysis of Basic Research and Technological Innovation in Synthetic Biology

作　　者：张雪 张志强[1,2] 陈秀娟 郭辰 Zhang Xue;Zhang Zhiqiang;Chen Xiujuan;Guo Chen(Chengdu Library and Information Center,Chinese Academy of Sciences,Chengdu 610041;Department of Library,Information and Archives Management,School of Economics and Management,University of Chinese Academy of Sciences,Beijing 100190;School of Information Management,Wuhan University,Wuhan 430072)

机构地区：[1]中国科学院成都文献情报中心,成都610041 [2]中国科学院大学经济与管理学院图书情报与档案管理系,北京100190 [3]武汉大学信息管理学院,武汉430072

出　　处：《情报学报》2020年第3期231-242,共12页Journal of the China Society for Scientific and Technical Information

基　　金：国家社会科学基金重点项目“面向领域知识发现的学科信息学理论与应用研究”(17ATQ008);中国科学院战略研究与决策支持系统建设专项“主要领域规划状态监测与分析”(GHJ-ZLZX-2020-31-1)。

摘　　要：通过论文及专利的交叉引用分析探讨合成生物学领域基础研究与技术创新的关联,为提高该领域基础研究及技术创新能力提供建议,为科技资源整合策略提供支持。本研究以论文、专利分别作为基础研究与技术创新的替代指标,以Web of Science和美国专利商标局中收录的近十年合成生物学领域共9033篇论文、5233件专利为研究对象,从引文整体分布情况、科学及技术关联度、引文时滞、循环周期四个角度对专利及论文引文进行分析,从主题分布情况对论文-专利混合共被引情况进行分析,力求多角度综合分析合成生物学领域基础研究与技术创新之间关联关系。研究结果表明,国际上合成生物学领域97%左右的技术创新引用了基础研究的理论成果,但仅有4%的基础研究引用了技术创新成果;科学关联度总体波动不大,而技术关联度尚未形成稳定的趋势,美国的科学关联度及技术关联度均优于其他国家,而我国较为落后;专利文献更倾向引用时滞小于15年的专利、小于13年的论文,论文文献更倾向引用时滞小于6年的专利、小于6年的论文;专利的技术循环周期为13.92年、科学循环周期为12.28年,论文的科学循环周期为6.99年、技术循环周期为10.85年;合成生物学领域基础研究与技术创新有相同的发展趋势,如均关注基因与基因组的合成、基因编辑等方面的研究,但基础研究关注范围更多、领域更广。因此未来需加强将技术创新成果运用到基础研究中,促进新的技术创新成果产出;加快基础研究及先前技术创新成果向技术创新的转化速度;引用新颖性更强的基础研究及技术创新成果,促进创新。This study discusses the relationship between basic research and technological innovation in the field of synthetic biology based on a cross-reference analysis of papers and patents, provides suggestions for improving the ability of basic research and technological innovations in this field, and supports the integration strategy of scientific and technological resources. Academic papers and patents are used as the substitute indicators of basic research and technological innovation.A total of 9033 papers and 5233 patents collected from the Web of Science and United States patent and trademark office are used as the research object. In order to comprehensively analyze the relationship between basic research and technological innovation in the field of synthetic biology, we analyze patent and paper citations from four perspectives: the overall distribution of citations, scientific and technical linkage, the time lag of citations, and the cycle time;and we analyze the topic distribution from the paper-patent mixed citation. Approximately 97% of technological innovations in the field of synthetic biology around the globe have cited the theoretical results of basic research, while only 4% of basic research have cited the technological innovations. The overall fluctuation of the science linkage is not volatile, but the technology linkage has not exhibited a stable trend. The science linkage and technology linkage of the United States are better than those of other countries, while that of China is relatively backward. The patents are more likely to cite other patents with a time lag of less than 15 years and papers with a time lag of less than 13 years. The papers are more likely to cite patents with a time lag of less than 6 years and papers with a time lag of less than 6 years. The technical cycle and scientific cycle of a patent are 13.92 and 12.28 years, respectively, while those of a paper are 10.85 and 6.99 years, respectively. Basic research in the field of synthetic biology shows a development trend similar to

关 键 词：基础研究 技术创新 交叉引用 关联分析 合成生物学 

分 类 号：Q819[生物学—生物工程]