纳米载体包载锌酞菁及其衍生物用于光动力抗癌的研究进展  

Research progress on nanocarrier-loaded zinc phthalocyanine and its derivatives for photodynamic anticancer

作　　者：卢小鸾 张荣 杨培昕 彭黔荣 汤陆扬 杨敏[1] LU Xiao-luan;ZHANG Rong;YANG Pei-xin;PENG Qian-rong;TANG Lu-yang;YANG Min(School of Medicine,Guizhou University,Guiyang 550025,China;Technology Center of China Tobacco Guizhou Industrial Co.,Ltd.,Guiyang 550009,China)

机构地区：[1]贵州大学药学院,贵州贵阳550025 [2]贵州中烟工业有限责任公司技术中心,贵州贵阳550009

出　　处：《化学研究与应用》2020年第3期341-350,共10页Chemical Research and Application

基　　金：国家自然科学基金项目(21562014)资助;贵州中烟科技项目(黔烟工技【2015】8号)资助。

摘　　要：锌酞菁(ZnPc)是一种高效的第二代光敏剂,具有良好的光物理和光化学性质,可用于癌症的光动力治疗(PDT)。然而,由于共轭分子间的π-π作用力,锌酞菁溶解性差、结晶趋势强,阻碍了其直接用药。为了克服这个问题,大量纳米载体被研究开发。本文旨在对近五年纳米载体包载锌酞菁及其衍生物用于光动力抗癌的研究进行综述,根据其与锌酞菁及其衍生物的相互作用分为基于聚离子复合的纳米载体、基于物理包封以及化学键合的纳米载体。Zinc phthalocyanine(ZnPc)is a highly efficient second-generation photosensitizer for cancer photodynamic therapy(PDT)with attractive photophysical and photochemical properties.However,due to theπ-πinteraction between the conjugated molecules,zinc phthalocyanine has poor solubility and strong crystallization tendency,which hinders its direct administration.In order to overcome this problem,a large number of nanocarriers had been researched and developed.This paper aimed to review the research of nanocarrier-loaded zinc phthalocyanine and its derivatives for photodynamic anticancer in the past five years.According to its interaction with zinc phthalocyanine and znic phthalocyanine derivatives,it was divided into polyionic composite,physical encapsulation and chemically bonded nanocarriers.

关 键 词：锌酞菁 纳米载体 聚离子复合 物理包封 化学键合 

分 类 号：O63[理学—高分子化学]