苯并三氮杂[艹卓]衍生物的合成研究  

Synthesis of benzotriazepine derivatives

作　　者：于姝燕 王敏 陈建平 王建华 张可青 郭晓宇 YU Shu-yan;WANG Min;CHEN Jian-ping;WANG Jian-hua;ZHANG Ke-qing;GUO Xiao-yu(College of Pharmacy,Inner Mongolia Medical University,Hohhot 010010,China)

机构地区：[1]内蒙古医科大学药学院,内蒙古呼和浩特010110

出　　处：《化学研究与应用》2020年第3期473-477,共5页Chemical Research and Application

基　　金：内蒙古自治区自然科学基金项目(2018MS02009)资助;内蒙古自治区大学生创新创业训练计划项目(201910132009)资助;内蒙古医科大学科技百万工程项目(YKD2017KJBW013)资助;内蒙古医科大学本科质量工程“教坛新秀”项目(NYJTXX201802)资助。

摘　　要：本文通过N-取代芳磺酰胺和N,N′-环氮甲基亚胺发生[4+3]环加成反应,得到了一种高效合成三环苯并三氮杂[艹卓]衍生物的方法。对该反应的条件如溶剂和碱进行了筛选,在最优条件下,考察了底物普适性,并合成了9个苯并三氮杂[艹卓]衍生物,收率为36~99%。所有目标化合物通过^1H NMR、^13C NMR和HRMS进行了结构确证。A[4+3]cycloaddition reaction of N,N′-cyclic azomethine imines with N-substituted aromatic sulfonamide had been developed.The text provided a rapid method for the synthesis of tricyclic benzotriazepines.The reaction conditions which mainly included solvent and base had been screened.Under the optimum reaction condition,nine tricyclic benzotriazepines had been obtained in 36~99%yield range.The structures of all target compounds were characterized by 1H NMR,13 C NMR and HRMS.

关 键 词：N-取代芳磺酰胺 N N′-环氮甲基亚胺 [4+3]环加成反应 苯并三氮杂[艹卓]衍生物 

分 类 号：O626[理学—有机化学]