Th9细胞/白细胞介素-9在特应性皮炎中免疫调节机制的研究进展  

Advances in Immunoregulation Mechanism of Th9 Cells/IL-9 in Atopic Dermatitis

作　　者：李晨阳[1] 齐瑞群[2] 彭戈 李琳[1] 韩秀萍[1] LI Chenyang;QI Ruiqun;PENG Ge;LI Lin;HAN Xiuping(Department of Dermatology,Shengjing Hospital of China Medical University,Shenyang 110004,China;Department of Dermatology,the First Hospital of China Medical University,Shenyang 110001,China;Atopy(Allergy)Research Center,Juntendo University Graduate School of Medicine,Tokyo 1130022,Japan)

机构地区：[1]中国医科大学附属盛京医院皮肤科,辽宁沈阳110004 [2]中国医科大学附属第一医院皮肤科,辽宁沈阳110001 [3]日本顺天堂大学大学院特应性疾病研究中心,日本东京1130022

出　　处：《中国皮肤性病学杂志》2020年第2期224-228,共5页The Chinese Journal of Dermatovenereology

基　　金：2017年辽宁省重点研发计划指导计划项目(2017225026)。

摘　　要：特应性皮炎(atopic dermatitis,AD)是一种多因素参与的慢性炎症性疾病,其发病机制复杂,主要由环境因素作用于遗传易感个体,造成免疫调节失常所致。Th9细胞是近年新定义的Th细胞亚群,主要通过分泌白细胞介素-9(Interleukin-9,IL-9)发挥生物学效应。IL-9作为一种多功能的促炎因子,在包括AD等免疫性皮肤疾病中发挥重要作用。本文就近年来Th9细胞的研究进展及其在AD免疫调节机制中的作用进行综述。Atopic dermatitis(AD)is a chronic inflammatory skin disease caused by multiple factors.While its pathogenesis is complex,AD’s primary etiology is linked with environmental factors affecting genetically susceptible individuals,resulting in abnormal immune regulation.Th9 cells represent a recently defined Th cell subset that exert biological effects mainly through the secretion of interleukin-9(IL-9).As a multifunctional pro-inflammatory factor,IL-9 plays an important role in immunemediated skin diseases,including AD.In this report we review recent advances in research on Th9 cells and their role in the immunoregulatory mechanisms underlying AD.

关 键 词：TH9细胞 IL-9 特应性皮炎 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]