院前应用普罗帕酮救治阵发性室上性心动过速的效果分析  

Analysis on effect of using pre-hospital propafenone emergency treatment for rescuing patients with paroxysmal supraventricular tachycardia

作　　者：张岩[1] Zhang Yan(Department of Pharmacy,Tianjin Hongqiao Hospital,Tianjin 300131,China)

机构地区：[1]天津市红桥医院药剂科,300131

出　　处：《中国中西医结合急救杂志》2019年第6期678-680,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

摘　　要：目的 观察普罗帕酮对院前急救过程中发生阵发性室上性心动过速(室上速)的治疗效果.方法 采用回顾性研究方法.选取2018年3月至2019年3月天津市红桥医院院前急救过程中出现室上速的患者76例,将患者按用药不同分为胺碘酮组和普罗帕酮组,每组38例.观察两组患者抢救有效率、心率恢复正常时间、治疗总时间、治疗前后心率水平及不良反应发生率.结果 普罗帕酮组总有效率明显高于胺碘酮组[94.74%(36/38)比73.68%(28/38),P<0.05].普罗帕酮组心率恢复正常时间和治疗总时间均明显短于胺碘酮组[心率恢复正常时间(h):7.14±1.84比12.56±2.56,治疗总时间(d):6.14±2.20比8.87±2.48,均P<0.05].普罗帕酮组和胺碘酮组患者治疗前心率比较差异无统计学意义(次/min:171.8±24.4比173.7±25.5,P>0.05),但治疗后普罗帕酮组心率明显低于胺碘酮组(次/min :112.9±7.5比138.4±9.0,P<0.05).普罗帕酮组不良反应发生率明显低于胺碘酮组[2.63%(1/38)比15.79%(6/38),P<0.05].结论 在院前急救中应用普罗帕酮治疗室上速可有效改善临床疗效,巨安全性高.Objective To observe the effect of propafenone for patients with paroxysmal supra-ventricular tachycardia(PSVT)during pre-hospital emergency rescue treatment.Methods A retrospective study was conducted.Seventy-six patients with occurrence of PSVT in the process of pre-hospital emergency treatment in Tianjin Hongqiao Hospital from March 2018 to March 2019 were selected.The patients were divided into amiodarone group and propafenone group according to the difference in medications,38 cases in each group.The effective rate of rescue,the time of recovery of normal heart rate,the total time of treatment,the levels of heart rate before and after treatment and the incidence of adverse reactions were observed in both groups.Results The total effective rate of propafenone group was significantly higher than that of amiodarone group[94.74%(36/38)vs.73.68%(28/38),P<0.05].The times of recovery of normal heart rate and total treatment of propafenone group were significantly lower than those of amiodarone group[times of recovery of normal heart rate(hours):7.14±1.84 vs.12.56±2.56,times of total treatment(days):6.14±2.20 vs.8.87±2.48,both P<0.05].Before treatment,there was no statistical significant difference in heart rate between propafenone group and amiodarone group(bpm:171.8±24.4 vs.173.7±25.5,P>0.05),but after treatment,the heart rate of propafenone group was significantly lower than that in amiodarone group(bpm:112.9±7.5 vs.138.4±9.0,P<0.05).The incidence of adverse reactions in propafenone group was significantly lower than that of amiodarone group[2.63%(1/38)vs.15.79%(6/38),P<0.05].Conclusion Application of propafenone in the pre-hospital emergency treatment of patients with PSVT can effectively improve their clinical efficacy,and its therapeutic safety is high.

关 键 词：普罗帕酮 院前急救 阵发性室上性心动过速 治疗有效率 不良反应 

分 类 号：R54[医药卫生—心血管疾病]