美沙酮维持治疗的海洛因成瘾者左侧执行控制网络功能特征的fMRI研究  

Characteristics of function of left executive control network in heroin addicts during methadone maintenance treatment: a restingstate fMRI study

作　　者：金龙 张微 黄玉芳[2] 王磊 魏熠鑫 李永斌[3] 刘为 李强 王玮 魏龙晓 JIN Long;ZHANG Wei;HUANG Yufang;WANG Lei;WEI Yixin;LI Yongbin;LIU Wei;LI Qiang;WANG Wei;WEI Longxiao(Nuclear Medicine Department of Tangdu Hospital,Air Force Military Medical University,Xi'an,710038,China;Radiology Department of The First Naval Hospital of Southern Theater Command,Zhanjiang 524009,China;Radiology Department of The Second Affliated Hospital of Xi'an Medical College,Xi'an,710038,China;Radiology Department of Tangdu Hospital,Air Force Military Medical University,Xi'an 710038,China)

机构地区：[1]空军军医大学唐都医院核医学科,西安710038 [2]中国人民解放军南部战区海军第一医院放射科,湛江524009 [3]西安医学院第二附属医院放射科,西安710038 [4]空军军医大学唐都医院放射科,西安710038

出　　处：《磁共振成像》2020年第3期166-170,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:81671661)。

摘　　要：目的探讨美沙酮维持治疗的海洛因成瘾者左侧执行控制网络功能连接的特点。材料与方法纳入21例美沙酮维持治疗的海洛因成瘾者与20例年龄、性别、教育程度相匹配的健康者,采用3.0 T磁共振设备进行静息态磁共振成像。首先,基于左侧执行控制网络感兴趣区计算全脑功能连接,分析两组间左侧执行控制网络功能连接差异,并进一步分析差异区功能连接值与海洛因吸食史和美沙酮治疗史的相关性。结果与健康组相比,美沙酮维持治疗的海洛因成瘾者的左侧背外侧前额叶与双侧背外侧前额叶功能连接增强(P<0.05,GRF校正),左侧后顶叶与左侧中央后回的功能连接增强。(P<0.05,GRF校正)。上述区域的功能连接强度值与海洛因吸食史和美沙酮治疗史无相关性(P值均>0.05)。结论美沙酮维持治疗的海洛因成瘾者左侧背外侧前额叶与双侧背外侧前额叶功能连接增强可能提示美沙酮有助于改善海洛因成瘾者的大脑执行控制功能,从而降低复吸风险;大脑左后顶叶与中央后回功能连接增强,可能是长期服用海洛因导致的对毒品线索刺激异常适应的表现。Objective: To investigate the characteristics of functional connectivity of left executive control network in heroin addicts during methadone maintenance treatment(MMT). Materials and Methods: Twenty-one heroin addicts during MMT(MMT group) and 20 healthy control subjects matched with age, sex and education level(HC group) were included in the resting-state functional magnetic resonance imaging(fMRI) study using 3.0 T magnetic resonance equipment. First of all, the functional connectivity of the whole brain were calculated based on the region of interest of the left executive control network, and the differences in functional connectivity of the left executive control network between the MMT group and HC group were analyzed. The correlation between the functional connectivity value of the different area and the history of heroin use and methadone treatment was further analyzed in MMT group. Results: The functional connectivity of the left executive control network of heroin addicts in MMT was stronger than that of the healthy subjects. The functional connectivity between the left dorsolateral prefrontal cortex and bilateral dorsolateral prefrontal cortex was enhanced(P<0.05, corrected with GRF), and the functional connectivity between the left posterior parietal cortex and the left postcentral gyrus was enhanced.(P<0.05, corrected with GRF). The functional connectivity strength in the above areas was not correlated with the history of heroin use and methadone treatment in MMT group(P>0.05 respectively). Conclusions: The enhanced functional connectivity between the left lateral dorsal prefrontal cortex and bilateraldorsal lateral prefrontal cortex of heroin addicts during MMT may suggest that methadone can help improve the brain’s executive control function and reduce the risk of relapse in heroin addicts. The enhanced functional connectivity between the left posterior parietal cortex and the postcentral gyrus might be a sign of abnormal adaptation to drug related cues due to long-term use of heroin.

关 键 词：海洛因依赖 美沙酮维持治疗 执行控制网络 磁共振成像 功能连接 

分 类 号：R445.2[医药卫生—影像医学与核医学] R322.81[医药卫生—诊断学]