NLRP3炎性小体在呼吸系统疾病中的研究进展  

Research Progress of NLRP3 Inflammasome in Respiratory Diseases

作　　者：张嘉诚 余佳[1] 李满[1] ZHANG Jiacheng;YU Jia;LI Man(Department of Hepatobiliary Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院肝胆外科,武汉430060

出　　处：《医学综述》2020年第5期845-849,855,共6页Medical Recapitulate

基　　金：中国留学基金委(留金发〔2017〕3059号);武汉市医学青年骨干人才项目(武卫生计生〔2016〕59号);武汉大学医学部大学生创新实验项目(MS2018014)。

摘　　要：炎性小体是一类介导宿主对微生物感染及细胞损伤免疫应答的蛋白复合体。近年来关于炎性小体核苷酸结合寡聚化结构域样受体家族中的核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎性小体的研究愈加广泛。NLRP3炎性小体可识别多种病原相关分子模式和损伤相关分子模式,进而激活下游的炎症通路,引发炎症反应,与慢性阻塞性肺疾病、感染性肺炎、哮喘、硅沉着病等常见呼吸系统疾病的发生、发展有着密切的联系。Inflammasome is a cytoplasmic macromolecular complex that orchestrates early inflammatory responses of the innate immune system against infection of microorganism and cell damage.Studies on nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)of the nucleotide binding oligomerization domain-like receptors family have been carried out extensively.It’s found that NLRP3 inflammasome can recognize many kinds of pathogen-associated molecular patterns and damage-associated molecular patterns,and then activate the downstream inflammatory pathway and trigger the inflammatory response,which is closely related to the respiratory system diseases such as chronic obstruct pulmonary disease,infectious pneumonia,asthma,silicosis etc.

关 键 词：核苷酸结合寡聚化结构域样受体蛋白3 炎性小体 呼吸系统疾病 

分 类 号：R563.9[医药卫生—呼吸系统]