黏膜固有免疫屏障在真菌性鼻窦炎发病中的研究进展  

Research Advances of Mucous Innate Immune Barrier in Pathogenesis of Fungal Rhinosinusitis

作　　者：刘海宁 杨国棠[1] 陈长康 杨贵[1] LIU Haining;YANG Guotang;CHEN Changkang;YANG Gui(Department of Otolaryngology,Shenzhen Longgang District Central Hospital,Shenzhen 518172,China;Shenzhen Clinical Medical College of Guangzhou University of Traditional Chinese Medicine,Shenzhen 518116,China)

机构地区：[1]深圳市龙岗中心医院耳鼻咽喉科,广东深圳518172 [2]广州中医药大学深圳临床医学院,广东深圳518116

出　　处：《医学综述》2020年第5期850-855,共6页Medical Recapitulate

基　　金：国家自然科学基金(31400856,81870706)。

摘　　要：真菌性鼻窦炎(FRS)是一种特异性鼻窦感染性疾病,近年来发病率逐年升高。黏膜固有免疫屏障(黏膜上皮屏障、固有免疫细胞、固有免疫分子)缺陷和真菌在鼻黏膜的定植均与FRS发病密切相关,因此,多种影响固有免疫的因素与适应性免疫之间的联系受到广泛关注。近年来,各型FRS发病机制的研究推动了FRS相关实验室诊断方法的发展,但目前FRS的具体发病机制尚不明确,且存在预防困难、漏诊误诊率较高、治疗不彻底等问题,患者的精神和经济负担均较重。Fungal rhinosinusitis(FRS)is a specific infection of the sinuses.In recent years,the incidence of FRS is increasing year by year.The defects of mucosal innate immune barrier(mucosal epithelial barrier,innate immune cells,innate immune molecules)and fungal colonization in nasal mucosa are closely related to the onset of FRS.Therefore,the relationship between various factors affecting innate immunity and adaptive immunity has been widely concerned.In recent years,the research on the pathogenesis of various types of FRS has promoted the development of laboratory diagnosis methods related to FRS,although the specific pathogenesis of FRS is still not clear,and there are problems such as difficult prevention,high misdiagnosis and missed diagnosis rate,incomplete treatment and so on,generating heavy mental and economic burden of the patients.

关 键 词：真菌性鼻窦炎 黏膜免疫 固有免疫 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]