心房颤动患者血清趋化素水平与心房纤维化程度的相关性  

Correlation between serum chemerin levels and degree of atrial fibrosis in patients with atrial fibrillation

作　　者：杨华[1] 孟利民[1] 信栓力[1] 常超[1] 赵秀峰[1] 王民 Yang Hua;Meng Limin;Xin Shuanli;Chang Chao;Zhao Xiufeng;Wang Min(First Department of Cardiology,Handan First Hospital,Handan 056000,China)

机构地区：[1]邯郸市第一医院心内一科,河北邯郸056000

出　　处：《临床荟萃》2020年第3期206-210,共5页Clinical Focus

基　　金：河北省医学科学研究课题计划Chemerin对心房颤动、肥胖、心房纤维化的影响及相关机制(20191798)。

摘　　要：目的探讨心房颤动(房颤)患者血清趋化素(chemerin)水平与心房纤维化程度的相关性。方法回顾性纳入CARTO指导的首次行导管射频消融术的阵发性或持续性房颤患者80例,根据有无低电压区将患者分为无低电压区组(n=32)和低电压区组(n=48),根据低电压区范围大小,低电压区组分为3个亚组:>5%≤20%(n=30)、>20%≤35%(n=12)、>35%(n=6),左心房低电压区范围反映心房纤维化程度;采用酶联免疫吸附法(ELISA)测定患者的血清chemerin水平。结果与无低电压区组相比,低电压区组的chemerin水平明显升高;>5%≤20%、>20%≤35%、>35%的chemerin水平差异有统计学意义(P<0.05),即低电压区范围越大,chemerin水平越高;相关性分析显示血清chemerin水平与低电压区范围呈正相关(r=0.721,P<0.01)。结论血清chemerin水平的高低可作为一种无创性的指标来评估心房纤维化程度,有助于临床选择合适的患者和消融术式。Objective To explore the correlation between serum chemerin levels and degree of atrial fibrosis in patients with atrial fibrillation(AF).Methods Eighty patients with AF undergoing CARTO-guided first catheter radiofrequency ablation for paroxysmal or persistent AF were enrolled.According to the presence or absence of low voltage areas,the patients were divided into non-low-voltage group(n=32)and low-voltage group(n=48).According to the range of low voltage area,the low-voltage group was divided into three subgroups:>5%≤20%(n=30),>20%≤35%(n=12),>35%(n=6).Low voltage area of left atrium reflects the degree of atrial fibrosis.Enzyme-linked immunosorbent assay(ELISA)was used to determine the serum chemerin levels of patients.Results Compared with non-low-voltage group,serum chemerin level was significantly increased in low-voltage group.The difference in chemerin levels between>5%≤20%,>20%≤35%,and>35%was statistically significant(P<0.05 for all).The larger the range of the low voltage area,the higher the chemerin level.Besides,correlation analysis showed that the serum chemerin level was positively correlated with the low-voltage range(r=0.721,P<0.01).Conclusion The level of serum chemerin can be used as a non-invasive index to evaluate the degree of AF,which is helpful for clinical selection of appropriate patients and ablation.

关 键 词：心房颤动 左心房低电压区 趋化素 心房纤维化 

分 类 号：R541.73[医药卫生—心血管疾病]