7-氯喹哪啶加合物的制备和溶解性研究  

Study on Preparation and Solubility of 7-chloroquinaldine Adducts

作　　者：何伟 许颖 李瑞华 卢玟玟 刘瑞 史洪伟 HE Wei;XU Ying;LI Rui-hua;LU Wen-wen;LIU Rui;SHI Hong-wei(Department of Chemical Engineering and Technology,Suzhou College,Anhui Suzhou 234000,China)

机构地区：[1]宿州学院化学化工学院,安徽宿州234000

出　　处：《广州化工》2020年第5期55-57,共3页GuangZhou Chemical Industry

基　　金：宿州学院国家级大学生创新创业训练计划项目(201910379020);宿州学院第十三届大学生科研项目(KYLXYBXM19-066);安徽省教育厅自然科学研究重点项目(KJ2016A888);宿州学院教授(博士)启动基金项目(2019jb03);宿州学院学术与技术带头人后备人选(2018XJHB03);宿州学院专业带头人(2019XJZY28)。

摘　　要：以7-氯喹哪啶、L-酒石酸盐和对硝基邻苯二甲酸为原料制备了7-氯喹哪啶加合物加合物,研究了加合物结构以及在溶剂中结晶的多晶型转变或溶剂化物形成。实验采用X射线衍射、热重分析、红外光谱、核磁共振分析表征。结果表明,产物具有预测结构,7-氯喹哪啶及其加合物在溶剂中结晶固相的所有XRD模式均衡,具有很好的溶解特性,为进一步提高同分异构体的分离效果奠定基础。The adducts of 7-chloro-quinaldine,l-tartrate and p-nitrophthalate were prepared. The structures of 7-chloro-quinaldine admixture and the crystallization of polycrystalline transition or solvate formation in solvent were studied. The experiment was characterized by X-ray diffraction,thermogravimetric analysis,infrared spectroscopy and nuclear magnetic resonance analysis. The results showed that the product had the predicted structure,the 7-chloro-quinaldine and its adducts were balanced with all the XRD patterns of the crystalline solid phase in the solvent,and it had a good solubility property,which laid a foundation for further improving the separation effect of isomers.

关 键 词：7-氯喹哪啶 加合物 溶解性 

分 类 号：O64[理学—物理化学]