益气运脾汤治疗溃疡性结直肠炎  被引量:3

Yiqi Yunpi Decoction in Treating Ulcerative Colorectitis

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作  者:赵义红 王菲[2] 娄静[2] ZHAO Yihong;WANG Fei;LOU Jing(The Affiliated Hospital to Henan Medical College,Zhengzhou Henan China 451191;The Affiliated Hospital to Henan Academy of Traditional Chinese Medicine,Zhengzhou Henan China 450004)

机构地区:[1]河南医学高等专科学校附属医院,河南郑州451191 [2]河南省中医药研究院附属医院,河南郑州450004

出  处:《中医学报》2020年第2期398-402,共5页Acta Chinese Medicine

基  金:河南省教育厅科学技术研究重点项目(15A360-019)。

摘  要:目的:观察益气运脾汤治疗溃疡性结直肠炎患者的临床疗效,并观察其对患者炎症因子、凝血功能、免疫功能、黏膜病变评分、中医证候评分的影响。方法:溃疡性结直肠炎患者94例,按随机数字表分为对照组和观察组各47例。对照组给予布地奈德混悬液保留灌肠,在对照组治疗基础上,观察组给予益气运脾汤治疗,两组均治疗4周。结果:观察组有效率为89.13%(41/46),对照组有效率为73.33%(33/45),两组有效率比较,差异有统计学意义(Z=2183,P=0.029<0.05)。与对照组比较,观察组治疗后的腹痛、腹泻、黏液脓血便、里急后重、肛门坠胀等中医证候评分更低(P<0.05),黏膜水肿、黏膜糜烂、黏膜溃疡、炎性增生等黏膜病变评分更低(P<0.05)。与对照组比较,观察组治疗后的肿瘤坏死因子-α、白细胞介素-4、白细胞介素-8、白细胞介素-27、D-二聚体、血小板、血小板平均体积、部分活化凝血活酶时间、CD3^+、CD8^+、IgA、IgG、IgM水平更低(P<0.05),γ-干扰素、白细胞介素-10、血小板平均体积、CD4^+、CD4^+/CD8^+水平更高(P<0.05)。结论:益气运脾汤治疗溃疡性结直肠炎临床疗效显著,能抑制患者炎症反应,改善血液高凝状态,提高免疫功能。Objective:To observe the clinical efficacy of Yiqi Yunpi Decoction in treatment of patients with ulcerative colorectitis and its effects on patients’inflammatory factors,coagulation function,immune function,scores of mucosal lesions,and scores of TCM syndromes.Methods:Ninety-four patients with ulcerative colorectitis were randomly divided into a control group and a treatment group with 47 cases each.The control group was given budesonide suspension retention enema.On the basis of the treatment of the control group,the observation group was given Yiqi Yunpi Decoction.Both groups were treated for 4 weeks.Results:The effective rate in the observation group was 89.13%(41/46),and the effective rate in the observation group was 73.33%(33/45).The effective rates of the two groups were compared,and the difference was statistically significant(Z=2183,P=0.029<0.05).Compared with the control group,the observation group had lower scores in TCM syndromes such as abdominal pain,diarrhea,mucus,pus and bloody stools,acute aftermath,and anal bulge(P<0.05),mucosal edema,mucosal erosion,mucosal ulcer,and inflammatory hyperplasia Lesion score was lower(P<0.05).Compared with the control group,the tumor necrosis factor-α,interleukin-4,interleukin-8,interleukin-27,D-dimer,platelet,mean platelet volume,partially activated coagulation activity,Enzyme time,CD3^+,CD8^+,IgA,IgG,IgM levels were lower(P<0.05),andγ-interferon,interleukin-10,average platelet volume,CD4^+,CD4^+/CD8^+levels were higher(P<0.05).Conclusion:Yiqi Yunpi Decoction has significant clinical effect in treating ulcerative colorectitis.It can inhibit patients’inflammatory response,improve blood hypercoagulability,and improve immune function.

关 键 词:益气运脾汤 溃疡性结直肠炎 炎症因子 凝血功能 黏膜病变评分 中医证候评分 免疫功能 

分 类 号:R259.746.3[医药卫生—中西医结合]

 

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