季鏻盐支载伯胺-硫脲双功能手性催化剂制备及其应用研究  

Preparation of Phosphonium Salts Supported Bifunctional Primary Amine-thiourea Chiral Catalyst and its Application

作　　者：金小红 章佳安 张玉霖 Jin Xiaohong;Zhang Jia'An;Zhang Yulin(College of Pharmacy,Hubei University of Science and Technology,Xianning437100,China)

机构地区：[1]湖北科技学院药学院,湖北咸宁437100

出　　处：《山东化工》2020年第4期45-47,52,共4页Shandong Chemical Industry

基　　金：2018年咸宁市科技计划引导性项目。

摘　　要：以可溶性季鏻盐为载体,合成了季鏻盐支载的伯胺-硫脲双功能手性催化剂,并将其应用于催化不对称Diels-Alder反应。对不对称催化反应条件和底物进行了优化和探讨,该催化反应具有较高的产率和立体选择性,且催化剂可通过简单的沉淀、过滤、干燥进行分离纯化并循环使用,在重复使用5次后,其催化活性未见明显降低。Phosphonium salts supported bifunctional primary amine-thiourea chiral catalyst was synthesized by using soluble phosphonium salts as support,and then applied to catalyze asymmetric Diels-Alder reation.By exploring the condition and substrate of the reacion,it demonstrated these reactions were in high yield and stereoselectivity.Moreover,the chiral catalyst could be separated and recycled by sample precipitation,filtration and drying,and after repeated use for 5 times,its catalytic activity did not decrease significantly.

关 键 词：季鏻盐 支载 伯胺-硫脲 手性催化剂 DIELS-ALDER反应 

分 类 号：O626[理学—有机化学]