pH响应聚合物胶束及其在抗肿瘤药物载体中的应用  

pH-responsive polymer micelles and applications in anti-tumor drug carriers

作　　者：王惊雷 宋柯 李杭 陈立江[1] WANG Jinglei;SONG Ke;LI Hang;CHEN Lijiang(College of pharmacy,Liaoning University,Shenyang 110036,China)

机构地区：[1]辽宁大学药学院,辽宁沈阳110036

出　　处：《中国药剂学杂志》2020年第1期49-61,共13页Chinese Journal of Pharmaceutics

基　　金：辽宁省教育厅创新人才支持计划项目(LR2017065);“建行杯”辽宁省第五届“互联网+”大学生创新创业大赛(D201904151939195865)。

摘　　要：对于许多抗肿瘤药物来说,其缺点主要是肿瘤靶向效率低、生物利用度差、全身毒性及不良反应强等。将其制备成具有靶向作用的缓控释药物制剂具有相当大的意义。其中pH响应聚合物胶束成为近年来抗肿瘤药物载药系统的热点。纳米级别的pH响应聚合物胶束载药系统依赖于肿瘤组织血管的渗透性和淋巴回流障碍(EPR)效应以及肿瘤部位中的低pH微环境,能够被动靶向治疗肿瘤。本文中综述了pH响应聚合物胶束的研究进展及其在肿瘤靶向药物中的应用。For many anti-tumor medicines,their disadvantages are obvious,including minimal tumor targeting efficiency,poor bioavailability,and strong systemic toxic side effects,ect.It is of great significance to develop targeted drug preparations for delivery and controlled release.pH-responsive polymer micelles,a nanoscaled drug delivery system,rely on the enhanced permeability and retention(EPR)effect of blood vessels in tumor tissues and the low-pH microenvironment in tumor tissues for passive targeted treatment,are becoming more and more prevalent in drug delivery systems.This paper reviews the research progress of pH-responsive polymer micelles and their applications in tumor-target.

关 键 词：药剂学 pH响应聚合物胶束 综述 抗肿瘤药物 药物递送 肿瘤靶向 纳米颗粒 

分 类 号：R94[医药卫生—药剂学]