“痫三针”联合奥卡西平对儿童癫痫部分性发作的临床疗效、脑电图和氧化应激的影响  

Clinical efficacy of “epilepsy three needles” combined with oxcarbazepine in the treatment of children with partial seizures of epilepsy and its influence on electroencephalogram and oxidative stress

作　　者：肖云斌[1] 应克伟 董勤[3] XIAO Yunbin;YING Kewei;DONG Qin(Department of Pediatrics,Affiliated Hospital of Hangzhou Normal University,Hangzhou,Zhejiang,310000,China;Department of Pediatrics,Wenzhou The People’s Hospital,Wenzhou,Zhejiang,325000,China;Department of Pediatrics,Zhejiang Hospital of TCM,Hangzhou,Zhejiang,310000,China)

机构地区：[1]杭州师范大学附属医院儿科,浙江杭州310000 [2]温州人民医院儿科,浙江温州325000 [3]浙江省中医院儿科,浙江杭州310000

出　　处：《中医儿科杂志》2020年第1期80-83,共4页Journal of Pediatrics of Traditional Chinese Medicine

摘　　要：目的观察"痫三针"联合奥卡西平对儿童癫痫部分性发作的临床疗效及对脑电图和氧化应激的影响。方法选取2013年1月至2017年12月杭州师范大学附属医院儿科、温州人民医院儿科、浙江省中医院儿科收治的110例癫痫部分性发作患儿作为研究对象,按照随机数字表法分为治疗组和对照组,各55例。对照组采用奥卡西平治疗,治疗组在对照组治疗方法的基础上采取"痫三针"疗法,2组均连续治疗2个月后,检测并比较2组治疗前后痫样放电与睡眠纺锤波频率,丙二醛(MDA)、超氧化物歧化酶(SOD)及谷胱甘肽(GSH)水平,随访1年,统计2组的临床疗效。结果治疗组总有效率为92.73%,对照组为74.55%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组1 h内脑电图痫样放电与睡眠纺锤波次数比较,差异无统计学意义,具有可比性(P>0.05);治疗后,2组1 h内脑电图痫样放电次数明显减少,睡眠纺锤波次数明显增加,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组减少或增加更显著(P<0.05)。治疗前,2组MDA、SOD、GSH水平比较,差异均无统计学意义(P>0.05),具有可比性;治疗后,2组MDA水平显著降低, SOD、GSH水平显著升高,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组降低或升高更显著(P<0.05)。结论 "痫三针"联合奥卡西平治疗儿童癫痫部分性发作疗效显著,可有效减少痫样放电,增加睡眠纺锤波,改善氧化应激水平,值得临床借鉴。Objective To observe the clinical efficacy of "epilepsy three needles" combined with oxcarbazepine in the treatment of children with partial seizures of epilepsy and its influence on electroencephalogram(EEG) and oxidative stress.Methods Totally 110 children with partial seizures of epilepsy admitted to pediatrics department of Affiliated Hospital of Hangzhou Normal University, pediatrics department of Wenzhou The People’s Hospital and pediatrics department of Zhejiang Hospital of TCM from January 2013 to December 2017 were chosen as research objects and divided into treatment group and control group according to random number table method, with 55 cases in each.The control group was given oxcarbazepine,on this basis,the treatment group was given "epilepsy three needles" therapy.After the 2 groups were both given consecutive treatment for 2 months,the frequency of epileptiform discharge and sleep spindle wave,the levels of malondialdehyde(MDA),superoxide dismutase(SOD) and glutathione(GSH) before and after treatment were detected and compared between the two groups.The patients were followed up for 1 year,and we kept statistics about the clinical efficacy of the 2 groups.Results The total effective rate of the treatment group was 92.73%,that of the control group was 74.55%,and the difference was statistically significant between the 2 groups(P<0.05).Before treatment,there was no significant difference in the number of epileptiform discharges and sleep spindle waves within 1 hour between the two groups(P>0.05),and they were comparable.After treatment,the number of epileptiform discharges within 1 hour of the 2 groups decreased significantly,while the number of sleep spindle waves increased significantly,and the difference was statistically significant compared with the same group before treatment(P<0.05), moreover,the treatment group decreased or increased more significantly(P<0.05).Before treatment,the difference was not statistically significant in the levels of MDA,SOD and GSH between the 2 groups(P>0.05),and

关 键 词：癫痫 部分性发作 儿童 “痫三针” 奥卡西平 脑电图 氧化应激 临床观察 

分 类 号：R272.6[医药卫生—中医儿科学]