基于扫频激光光源的皮肤血流OCT成像系统研制与应用  

Development and application of optical coherence tomography imaging system for skin blood flow based on swept laser source

作　　者：李奇原 任天慧 李易陆 王立伟[1] 李跃杰[1] LI Qi-yuan;REN Tian-hui;LI Yi-lu;WANG Li-wei;LI Yue-jie(Chinese Academy of Medical Science&Peking Union Medical College Institute of Biomedical Engineering,Tianjin 300192,China)

机构地区：[1]中国医学科学院北京协和医学院生物医学工程研究所,天津300192

出　　处：《医疗卫生装备》2020年第3期38-42,共5页Chinese Medical Equipment Journal

基　　金：天津市生物医学工程科技重大专项(18ZXSGSY00050);中国医学科学院医学与健康科技创新工程(协同创新团队项目)(2017-I2M-3-020)。

摘　　要：目的:针对皮肤组织的光谱吸收特性,研制一套基于扫频激光光源的皮肤血流光学相干断层扫描(optical coherence tomography,OCT)成像系统,实现皮肤组织2D/3D结构成像及微血管血流成像。方法:该系统由扫频激光光源及干涉仪组成的光学系统模块、光电探测器及数据采集卡组成的信号采集模块、计算机及控制卡组成的系统控制模块以及图像处理模块构成。系统采用中心波长为1310 nm的扫频激光光源,通过对采集到的与皮肤组织结构及微血管血流相关的光相干扫描信号进行色散补偿、逆傅里叶变换及去相关标准差运算等数据处理,实现皮肤组织结构与微血流成像。结果:利用该系统对人体皮肤组织进行实时成像研究,其扫描频率为100 kHz,纵向分辨力可达6μm,可清晰显示皮下分层与血管组织;利用去相关标准差算法处理,该系统可实现皮下微血流信息的提取与成像。结论:该系统实现了皮肤组织结构与微血流成像,为浅表皮肤病与外周动脉疾病的临床诊断奠定了实验基础。Objective To develop a skin tissue structure and microvascular blood flow optical coherence tomography(OCT)system based on the spectral absorption characteristics of skin tissue and sweep laser source to realize skin tissue 2D/3D structure imaging and microvascular blood flow imaging.Methods An OCT imaging system was developed composed of an optical system module consisting of a swept laser source and an interferometer,a signal acquisition module including a photodetector and a data acquisition card,a system control module composed of a computer and a control card as well as an image processing module.The system with a central wavelength of 1310 nm realized the imaging of skin tissue structure and microvascular blood flow by data processing such as dispersion compensation,inverse Fourier transform and de relative standard deviation computation for the collected optical coherent scanning signals related to skin tissue structure and microvascular blood flow.Results The system proved to display the subcutaneous layer and vascular tissue clearly at real time with 100 kHz scan frequency and 6μm longitudinal resolution;de relative standard deviation facilitated information extraction and imaging for subcutaneous microcirculation blood flow.Conclusion The system can realize skin tissue structure and micro blood flow imaging,which lays an experimental foundation for clinical diagnoses of superficial skin diseases and peripheral arterial diseases.

关 键 词：光学相干断层扫描 扫频激光光源 皮肤成像 微血流成像 去相关算法 

分 类 号：R318[医药卫生—生物医学工程] R445[医药卫生—基础医学]