手性硫脲催化不对称合成多取代呋喃酮  

Chiral thiourea-catalyzed asymmetric synthesis of furanone

作　　者：黄忠杰 HUANG Zhongjie(College of Chemistry,Chemical Engineering and Environment,Minnan Normal University,Zhangzhou,Fujian 363000,China)

机构地区：[1]闽南师范大学化学化工与环境学院,福建漳州363000

出　　处：《闽南师范大学学报（自然科学版）》2020年第1期56-60,共5页Journal of Minnan Normal University：Natural Science

摘　　要：在甲苯溶剂中,在醋酸钾及手性硫脲的协同作用下,(E)-4-甲氧基-β-硝基苯乙烯与β-溴代乙酰乙酸乙酯经过串联的反应制备出手性的呋喃酮产物.该反应只需要一步串联的Michael-5-exo-trig环化反应就能有效地构建不对称的呋喃酮产物.A cascade reaction of(E)-1-methoxy-4-(2-nitrovinyl)benzene and ethyl 4-bromo-3-oxobutanoate was designed for the enantioselective synthesis of furanone with the synergistic interactions of chiral thiourea and KOAc in toluene.The reaction underwent efficiently a domino Michael-5-exo-trig cyclization process to deliver the asymmetric furanone in one step.

关 键 词：呋喃酮 手性硫脲 关环反应 

分 类 号：O622[理学—有机化学]