宁夏回族自治区正常人群四项肝功能项目通用参考区间的调查研究  

Investigation on the Common Reference Intervals of Four Liver Function Tests of Normal Population in Ningxia Hui Autonomous Region

作　　者：董璐艳 李锋 袁笑[1] 白玉[1] 杨萍 彭新国[1] DONG Lu-yan;LI Feng;YUAN Xiao;BAI Yu;YANG Ping;PENG Xin-guo(Department of Clinical Laboratory,Affiliated Hospital of Binzhou Medical University,Shangdong Binzhou 256600,China,2(1.Department of Clinical Laboratory,Affiliated Hospital of Binzhou Medical University,Shangdong Binzhou 256600,China;Department of Clinical Laboratory,General Hospital of Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]滨州医学院附属医院检验科,山东滨州256600 [2]宁夏医科大学总医院医学实验中心,银川750004

出　　处：《现代检验医学杂志》2020年第1期115-119,共5页Journal of Modern Laboratory Medicine

基　　金：宁夏地区基层医院检验科卫生服务现状研究(2016003)。

摘　　要：目的探索宁夏回族自治区建立四项肝功能项目通用参考区间(RI)的可行性。方法收集2015年10月~2016年12月宁夏回族自治区六家医院体检人群包括该研究中四项肝功能[总蛋白(TP)、清蛋白(ALB)、丙氨酸氨基转移酶(ALT)和天门冬氨酸转移酶(AST)]结果在内的相关体检数据。确定参考人群,采用三级嵌套方差分析(3-Level Nested ANOVA)确定是否需要分组,最终使用非参数法建立该地区RI。比较新建与现用RI及其他多中心研究结果的差异。结果TP的SDR-地区、SDR-性别、SDR-年龄分别是0.25,0.01和0.07;ALB的SDR-地区、SDR-性别、SDR-年龄分别是0.18,0.26和0.27;TP及ALB在地区、年龄及性别间差异无统计学意义(均SDR<0.3)。ALT的SDR-地区、SDR-性别、SDR-年龄分别是0.31,0.44和0.03;AST的SDR-地区、SDR-性别、SDR-年龄分别是0.34,0.31和0.25,ALT及AST在地区及性别间差异有统计学意义(SDR均>0.3)。除银川市外,其余五地ALT,AST的新建与现用RI及其他多中心研究结果存在一定的差异(上、下限差异>10%)。结论可在该地区建立TP,ALB的通用RI,但需进一步验证;因ALT,AST存在地域差异,需分组建立RI。某些地区ALT,AST的新建与现用RI不一致,需对其现用RI进行验证。Objective The purpose of this study was to explore the feasibility of establishing common reference intervals for four liver function tests in Ningxia Hui Autonomous Region using data from the physical examination population. Methods Collected the physical examination data of six hospitals in Ningxia Hui Autonomous Region including 4 liver functions [total protein( TP),albumin( ALB),alanine aminotransferase in this study( ALT),and aspartate transferase( AST) ]from October 2015 to December 2016. Identify the reference population,and applied a 3-level nested ANOVA to determine if grouping is required,the reference intervals in this region were established using nonparametric method Finally. Compared the differences between the new and current reference intervals and other multicenter studies. Results The SDR-region,SDR-gender and SDR-age of TP were 0. 25,0. 01 and 0. 07 respectively,the SDR-region,SDR-gender,and SDR-age of ALB were 0. 18,0. 26 and 0. 27,respectively. There was no statistic difference between region,age and gender in TP and ALB( SDRs were all< 0. 3). The SDR-region,SDR-sex and SDR-age of ALT were 0. 31,0. 44 and 0. 03 respectively,the SDR-region,SDRsex,and SDR-age of AST were 0. 34,0. 31 and 0. 25,respectively. Significant differences between region and gender were observed in ALT and AST( SDRs were all > 0. 3). There were some differences between the new and current reference intervals and other multi-center research results of ALT and AST in the other five places except Yinchuan( the differences between lower limits or upper limits was more than 10%). Conclusion Common reference intervals of TP and ALB can be established in this region,but further verification is needed. Due to regional differences in ALT and AST,RI needs to be established in groups. In some areas,the new and current reference intervals of ALT and AST are inconsistent,and further verification of the current reference intervals is required.

关 键 词：正常人群 宁夏回族自治区 肝功能 参考区间 

分 类 号：R446.12[医药卫生—诊断学]