中性粒细胞杀菌机理的最新研究进展  

Recent Research Progress on Germicidal Mechanism of Neutrophils

作　　者：时小淋 王晓丰 刘鹏 程艳杰[3] 王明义 SHI Xiao-lin;WANG Xiao-feng;LIU Peng;CHENG Yan-jie;WANG Ming-yi(Department of Central Laboratory,Weihai Municipal Hospital Affiliated to Dalian Medical University,Shandong Weihai 264200,China;Department of Gastroenterology,Weihai Municipal Hospital Affiliated to Dalian Medical University,Shandong Weihai 264200,China;Department of Clinical Laboratory,the First Affiliated Hospital of DalianMedical University,Liaoning Dalian 116000,China)

机构地区：[1]大连医科大学附属威海市立医院中心实验室,山东威海264200 [2]大连医科大学附属威海市立医院消化内科,山东威海264200 [3]大连医科大学附属第一医院检验科,辽宁大连116000

出　　处：《现代检验医学杂志》2020年第1期161-164,共4页Journal of Modern Laboratory Medicine

基　　金：威海市医学微生物与免疫学重点实验室;威海市科技发展计划:H.pylori tfs分泌系统结合区分子结构和功能研究(2016GNS029)。

摘　　要：中性粒细胞作为外周血中最多的白细胞,在机体免疫应答抵抗外界感染中发挥重要作用。目前,普遍认为中性粒细胞主要通过活性氧杀菌途径、脱颗粒杀菌途径和胞外杀菌网络(Neutrophil Extracellular Traps,NETs)途径杀灭病原体,若其杀菌途径缺失或抑制将导致反复感染,若过度激活也将对机体造成损伤。该文主要针对中性粒细胞杀菌机理的最新研究进展作以综述,以期为后续的中性粒细胞过度激活后具体作用途径以及作用靶点的研究提供理论基础。Neutrophils,as the largest number of white blood cells in the peripheral blood,play an important role in the immune response to external infection. At present,it was generally believed that Neutrophil Extracellular Traps( NETs) mainly kill pathogens through reactive oxygen species sterilization pathway,degranulation sterilization pathway and NETs pathway. If the lack or inhibition of NETs pathway will lead to repeated infection,and if the excessive activation will also cause damage to the body. This paper reviews the latest research progress on the germicidal mechanism of neutrophils in order to provide a theoretical basis for the follow-up studies on the specific action pathway and target of neutrophil overactivation.

关 键 词：中性粒细胞 杀菌机制 活性氧分子 脱颗粒 胞外杀菌网络 

分 类 号：R446.1[医药卫生—诊断学]