益心安神汤对睡眠及睡眠时相的影响  

Study on the Effects of Yixin Anshen Tang on Sleep and Sleep Phase

作　　者：崔健[1] 韦丽富 马家宝[1] 王有琼 梁霜[1] 杨正腾[1] CUI Jian;WEI Lifu;MA Jiabao;WANG Youqiong;LIANG Shuang;YANG Zhengteng(the First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China)

机构地区：[1]广西中医药大学第一附属医院,广西南宁530023

出　　处：《西部中医药》2020年第1期18-20,共3页Western Journal of Traditional Chinese Medicine

基　　金：广西中医药民族医药自筹经费科研课题(GZZC15-07)。

摘　　要：目的:探讨益心安神汤对睡眠及睡眠时相的影响。方法:通过小鼠翻正实验及大鼠脑电波分析方法,分别记录小鼠睡眠潜伏期、持续时间及大鼠睡眠时相的觉醒期(the waking phase of sleep,WAKE)、慢波睡眠第一期(slow-wave sleep phase 1,SWS1)、慢波睡眠第二期(slow-wave sleep phase 2,SWS2)、快速眼球运动睡眠期(rapid eye movement sleep,REMS)。结果:益心安神汤在戊巴比妥纳的诱导下能延长小鼠睡眠持续时间,但对睡眠潜伏期未产生影响,能缩短正常大鼠及失眠大鼠睡眠周期wake期,延长SWS1、SWS2及REMS期。结论:益心安神汤能增加小鼠及失眠大鼠的睡眠持续时间。Objective:To discuss the effects of Yixin Anshen Tang on sleep and sleep phase.Methods:Mice righting reflex and rat brain wave analysis method were used to record mice sleep latency,duration,the phases of WAKE,slow wave sleep in phase one(SWS1),slow wave sleep in phase two(SWS2)and rapid eye movement sleep(REMS)of rats.Results:Yixin Anshen Tang could prolong mice sleep duration induced by carbrital,but produce no effects on sleep latency,it could shorten wake phase of normal rats and insomnia rats in sleep cycle,and prolong the phases of SWS1,SWS2 and REMS.Conclusion:Yixin Anshen Tang could increase sleep duration of mice and insomnia rats.

关 键 词：失眠 催眠 睡眠时相 戊巴比妥纳 益心安神汤 大鼠 

分 类 号：R692[医药卫生—泌尿科学]