一种可用于检测2,4,6-三硝基苯酚的杂环芳族卤化物小分子荧光探针  

A Heterocyclic Aromatic Halide Small Molecule Fluorescent Probe for the Detection of 2,4,6-Trinitrophenol

作　　者：董子越 周晓霞[1] 赵晓慧 叶达莹 安悦[1] DONG Ziyue;ZHOU Xiaoxia;ZHAO Xiaohui;YE Daying;AN Yue(College of Chemistry and Chemical Engineering,Liaoning Normal University,Dalian,Liaoning 116029,China)

机构地区：[1]辽宁师范大学化学化工学院,辽宁大连116029

出　　处：《应用化学》2020年第3期332-339,共8页Chinese Journal of Applied Chemistry

基　　金：辽宁省科技厅自然基金指导计划项目(2019-ZD-0470)资助。

摘　　要：以2,6-二甲氧基苯甲酸为起始原料得到氨基噻二唑衍生物,通过Gattermann反应合成一种杂环芳族卤化物2-氯-5-(3-氯-2,6-二甲氧基苯基)-1,3,4-噻二唑(L),利用核磁共振波谱仪(NMR)和高分辨率质谱仪(HRMS)等测试手段确定了结构,并将其用作小分子荧光探针检测2,4,6-三硝基苯酚(TNP),系统地研究了其荧光特性,并且结合理论计算,探究了其可能的猝灭机制。研究结果表明,探针L对TNP具有高选择性、高灵敏度、抗干扰能力强,在较宽的pH值范围内,仍然表现出良好的荧光性能。具有较低的检测限(4.2×10^-7 mol/L),可用于实际水样中TNP的检测。The heterocyclic aromatic halide,2-chloro-5-(3-chloro-2,6-dimethoxyphenyl)-1,3,4-thiadiazole(L),was synthesized by Gattermann reaction from the aminothiadiazole derivative.Its structure was characterized by nuclear magnetic resonance spectroscopy(NMR)and high resolution mass spectrometry(HRMS).Probe L was used as a small molecule fluorescent probe to detect 2,4,6-trinitrophenol(TNP),and its fluorescence characteristics were systematically studied.Furthermore,combined with theoretical calculations,the possible quenching mechanism was explored.The results showed that the probe L had high seletivity,high sensitivity and strong anti-interference ability to TNP,and exhibited good fluorescence performance in a wide pH range.It has lower detection limit(4.2×10^-7 mol/L)and can be used for the detection of TNP in actual water samples.

关 键 词：杂环芳族卤化物 荧光探针 2 4 6-三硝基苯酚 理论计算 

分 类 号：O626[理学—有机化学]