盐酸米诺环素联合知柏地黄丸对慢性牙周炎合并冠心病患者冠脉病变程度及牙周炎控制的影响  

Effects of Minocycline Hydrochloride Combined with ZhibaiDihuang Pill on the Progress of Coronary Artery Disease and Periodontitis in Patients with Chronic Periodontitis Complicated by Coronary Heart Disease

作　　者：王延镯 岳二丽 WANG Yan-zhuo;YUE Er-li(Department of General Surgery,Henan Seth Dental Hospital,Zhengzhou 450000,China;Department of Periodontology,First Affiliated Hospital of Zhengzhou University(Henan Stomatological Hospital),Zhengzhou 450000,China)

机构地区：[1]河南赛思口腔医院综合科,郑州450000 [2]郑州大学第一附属医院(河南省口腔医院)牙周科,郑州450000

出　　处：《中国合理用药探索》2020年第3期56-59,共4页Chinese Journal of Rational Drug Use

基　　金：2016年度河南省医学科技攻关计划项目(201602091)。

摘　　要：目的:分析盐酸米诺环素联合知柏地黄丸对慢性牙周炎合并冠心病(CAD)患者冠脉病变程度及牙周炎控制的影响。方法:选取本院2017年10月~2019年10月收治的120例慢性牙周炎合并CAD患者作为研究对象,随机平均分为两组,对照组60例患者采用盐酸米诺环素治疗,研究组60例患者采用盐酸米诺环素联合知柏地黄丸治疗,对比两组临床疗效、牙周指数指标、冠脉狭窄评分、龈沟炎症因子。结果:研究组临床总有效率(96.67%)高于对照组(78.33%),治疗2周后研究组的临床附着丧失(CAL)、龈沟出血指数(SBI)、菌斑指数(PLI)、牙周探诊深度(PD)、冠脉狭窄评分以及龈沟肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)、白细胞介素-6(IL-6)均低于对照组(P<0.05)。结论:盐酸米诺环素联合知柏地黄丸可有效改善慢性牙周炎合并CAD患者牙周症状,减轻冠脉病变程度及牙周炎症。Objective:To analyze the effects of minocycline hydrochloride combined with ZhibaiDihuang pills on the progressof coronary artery disease and periodontitis in patients with chronic periodontitis complicated with coronary heart disease(CAD).Methods:From October 2017 to October 2019,82 patients with chronic periodontitis combined with CAD were included into the study and divided into 2 groups.Forty-one patients in the control group were treated with minocycline hydrochloride,while the test group were additionally given ZhibaiDihuang pill on that bases.The clinical efficacy,periodontal index,coronary stenosis score,and gingival sulcus inflammation factor were compared between the two groups.Results:The total clinical effective rate in the test group(96.67%)was significantly higher than that in the control group(78.33%).After 2 weeks of treatment,CAL,SBI,PLI,PD,coronary stenosis score,sulcus TNF-α,IFN-γ,IL-6 in the experimental group were significantly lower than those in the control group(P<0.05).Conclusion:Minocycline hydrochloride combined with ZhibaiDihuang pill can effectively improve the periodontal symptom,reduce the progress of coronary artery disease and periodontal inflammation in patients with chronic periodontitis combined with CAD.

关 键 词：盐酸米诺环素 知柏地黄丸 慢性牙周炎 冠心病 冠脉病变程度 牙周炎症 

分 类 号：R988.2[医药卫生—药品]