氟乙酸钠衍生物LC-MS/MS检验方法研究  

Discussion on the method ofsodium fluoroacetate derivatives detection by LC-MS/MS

作　　者：叶树海 朱怀恩 李航麒[1] 林坚[1] 林葭 庄顺[1] 郭明[1] Ye Shu-hai;Zhu Huai-en;Li Hang-qi;Lin Jian;Lin Jia;Zhuang Shun;Guo Ming(Institute of Forensic Science of Fujian Public Security Department,Fuzhou,Fujian 350003,China;AB SCIEX,Shanghai 200137,China)

机构地区：[1]福建省公安厅物证鉴定中心,福建福州350003 [2]AB SCIEX公司,上海200137

出　　处：《福建分析测试》2020年第1期13-17,共5页Fujian Analysis & Testing

基　　金：公安部技术研究计划(No.2016JSYJB14)。

摘　　要：本文采用DEPA和DDC对氟乙酸钠进行衍生,通过高分辨质谱系统发现并确定衍生物母离子和大多数子离子后,用串联四级杆复合线性离子阱质谱对其进行参数优化,建立LC-MS/MS的定性方法。随后,分别对水相衍生体系和有机相衍生体系的灵敏度进行评估。实验证明,后者的衍生物提取率只有前者的0.75%。A method for the determination of Sodium Fluoroacetate was developed using a derivative reaction with DEPA and DDC.Then the derivative was identified by a High Resolution Mass Spectrometry,the precursor ion and product ions were found and confirmed by the accuracy m/z.After optimization of the spectrometry parameters,a quantitation method was developed by a QTRAP system.With the experiment,the extraction rate in aqueous phase is only 0.75%of that in or ganic phase.

关 键 词：氟乙酸钠 液相色谱质谱 飞行时间质谱 衍生法 

分 类 号：O657.71[理学—分析化学]