去铁酮联合去铁胺治疗重症地中海贫血患儿的临床效果  

Clinical effect of Desferridone combined with Desferrimide in the treatment of children with severe thalassemia

作　　者：罗玉婷 陈捷 梁达开 戴本启 LUO Yu-ting;CHEN Jie;LIANG Da-kai;DAI Ben-qi(Department of Pediatrics,Yangjiang People′s Hospital of Guangdong Province,Yangjiang529500,China)

机构地区：[1]广东省阳江市人民医院儿科,广东阳江529500

出　　处：《中国当代医药》2020年第7期142-144,共3页China Modern Medicine

摘　　要：目的探讨去铁酮联合去铁胺治疗重症地中海贫血患儿的临床效果。方法选取2017年2月~2018年1月我院收治的50例重症地中海贫血患儿的临床资料进行回顾性分析,按照治疗方法的不同分为观察组(25例)与对照组(25例)。观察组患儿采用去铁酮联合去铁胺治疗,对照组患儿采用去铁胺治疗。比较两组患儿的治疗总有效率、不良反应总发生率、血清铁蛋白(SF)以及尿铁排泄量情况。结果观察组患儿的治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组患儿治疗前的SF浓度及尿铁排泄量比较,差异无统计学意义(P>0.05);观察组患儿治疗后的SF浓度低于对照组,尿铁排泄量高于对照组,差异有统计学意义(P<0.05);两组患儿的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论去铁酮联合去铁胺治疗重症地中海贫血患儿的效果确切,可降低患儿的铁负荷,且安全性较好,值得推广应用。Objective To investigate the clinical effect of Desferridone combined with Desferrimide in the treatment of children with severe thalassemia.Methods The clinical data of 50 children with severe thalassemia admitted to our hospital from February 2017 to January 2018 were analyzed retrospectively.According to different treatment methods,they were divided into observation group(25 cases)and control group(25 cases).The children in the observation group were treated with Desferridone and Deferoxamine,while the children in the control group were treated with Deferoxamine.The total effective rate,adverse reactions,serum ferritin(SF)and urinary iron excretion were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in SF concentration and urinary iron excretion before treatment between the two groups(P>0.05).After treatment,the SF concentration in the observation group was lower than that in the control group,and the urinary iron excretion was higher than that in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The effect of desferridone combined with deferoxamine in the treatment of severe thalassemia is exact,which can reduce the iron load of children and has good safety.It is worthy of popularization and application.

关 键 词：去铁酮 去铁胺 重症地中海贫血 治疗效果 不良反应 

分 类 号：R473.72[医药卫生—护理学]