益肺汤治疗慢性支气管肺炎的效果  

Effect of Yifei Decoction in the treatment of chronic bronchial pneumonia

作　　者：牛利东 海江 NIU Li-dong;HAI Jiang(Department of Pharmacy,Fuxin Trauma Emergency Hospital,Liaoning Province,Fuxin123000,China;Department of Internal Medicine,Fuxin Traditional Chinese Medicine Hospital,Liaoning Province,Fuxin123000,China)

机构地区：[1]辽宁省阜新市创伤急救医院药剂科,辽宁阜新123000 [2]辽宁省阜新市中医医院内科,辽宁阜新123000

出　　处：《中国当代医药》2020年第7期181-184,共4页China Modern Medicine

摘　　要：目的探究益肺汤治疗慢性支气管肺炎的效果。方法选取2014年3月~2019年7月于辽宁省阜新市创伤急救医院进行治疗的50例慢性支气管肺炎患者作为研究对象,采用随机数字表法将其分为对照组和观察组,每组各25例。对照组患者行西医治疗,观察组患者在对照组的基础上加用益肺汤治疗。比较两组患者的临床疗效、治疗前后中医证候积分、炎性因子[白介素-2(IL-2)、白介素-4(IL-4)、白介素-10(IL-10)、干扰素-γ(IFN-γ)]及肺功能指标[第1秒用力呼气量(FEV1)、最大呼气流量(PEF)、FEV1占用力肺活量比值(FEV1/FVC)]水平。结果观察组患者的治疗总有效率为92.00%,高于对照组的68.00%,差异有统计学意义(P<0.05)。观察组患者治疗后的中医证候积分为(3.42±0.78)分,低于对照组的(6.57±0.93)分,差异有统计学意义(P<0.05)。观察组患者治疗后的IL-2水平为(50.82±5.74)pg/ml,IFN-γ水平为(28.96±4.52)pg/ml,均高于对照组的(41.26±5.38)、(24.87±2.16)pg/ml,IL-4水平为(34.80±3.79)pg/ml,IL-10水平为(23.50±3.53)pg/ml,均低于对照组的(39.58±4.12)、(29.42±4.35)pg/ml,差异有统计学意义(P<0.05)。观察组患者治疗后的FEV1为(1.98±0.62)L,PEF为(65.37±6.28)L/min,FEV1/FVC为(63.27±6.42)%,均高于对照组的(1.67±0.33)L、(58.42±5.83)L/min、(57.48±6.15)%,差异有统计学意义(P<0.05)。结论益肺汤可有效改善慢性支气管肺炎患者炎性因子及肺功能,临床疗效确切,值得推广应用。Objective To investigate the effect of Yifei Decoction in the treatment of chronic bronchial pneumonia.Methods A total of 50 patients with chronic bronchial pneumonia who were treated in Fuxin Trauma Emergency Hospital of Liaoning Province from March 2014 to July 2019 were selected as the research subjects,and they were divided into the control group and the observation group according to the random number table method,with 25 cases in each group.The control group was treated with Western medicine,and the observation group was treated with Yifei Decoction on the basis of the control group.The clinical efficacy,traditional Chinese medicine syndrome scores,inflammatory factors(interleukin-2[IL-2],interleukin-4[IL-4],interleukin-10[IL-10],interferon-γ[IFN-γ])and levels of pulmonary function indicators(forced expiratory volume in the first second[FEV1],peak expiratory flow[PEF],FEV1 occupying forced vital capacity[FEV1/FVC])before and after treatment were compared in the two groups.Results The total effective rate of treatment in the observation group was 92.00%,which was higher than 68.00%in the control group,and the difference was statistically significant(P<0.05).The traditional Chinese medicine syndrome score of patients in the observation group after treatment was(3.42±0.78)points,which was lower than that in the control group for(6.57±0.93)points,and the difference was statistically significant(P<0.05).The IL-2 level after treatment in the observation group was(50.82±5.74)pg/ml,the IFN-γlevel was(28.96±4.52)pg/ml,which were higher than those in the control group for(41.26±5.38)and(24.87±2.16)pg/ml,and IL-4 level was(34.80±3.79)pg/ml,IL-10 level was(23.50±3.53)pg/ml,which were lower than those in the control group for(39.58±4.12)and(29.42±4.35)pg/ml,the differences were statistically significant(P<0.05).After treatment,the FEV1 in the observation group was(1.98±0.62)L,the PEF was(65.37±6.28)L/min,and the FEV1/FVC was(63.27±6.42)%,which were higher than those in the control group for(1.67±0.33)L,

关 键 词：慢性支气管肺炎 益肺汤 盐酸氨溴索口服溶液 头孢哌酮钠舒巴坦钠 炎性因子 肺功能 

分 类 号：R562.21[医药卫生—呼吸系统]