果纳芬分次给药对卵巢低反应患者临床结局的影响  

Clinical outcomes of patients with low ovarian response after multiple dosing of gonafine

作　　者：张克荣 常秀梅 邓少婷 蔡昭炜 ZHANG Kerong;CHANG Xiumei;DENG Shaoting;CAI Zhaowei(Department of Obstetrics, Gynecology and Reproductive Medicine, Second Clinical Medical College, Guangdong Medical University, Dongguan 523808, China;Department of Stomatology, Second Clinical Medical College, Guangdong Medical University, Dongguan 523808, China;Reproductive Medicine Center, Dongguan Third People's Hospital, Dongguan 523320, China)

机构地区：[1]广东医科大学第二临床医学院妇产科与生殖医学教研室,广东东莞523808 [2]广东医科大学第二临床医学院口腔医学教研室,广东东莞523808 [3]东莞市第三人民医院生殖医学中心,广东东莞523320

出　　处：《黑龙江医药科学》2019年第6期130-132,共3页Heilongjiang Medicine and Pharmacy

摘　　要：目的:探讨卵巢低反应患者接受体外受精-胚胎移植治疗时,每日将促性腺激素300IU单次给药和150IU两次给药两种不同方式对体外受精-胚胎移植临床结局的影响。方法:将接受常规体外受精-胚胎移植的卵巢低反应患者按照Gn用药次数分组,A组选择促性腺激素300IU,每日单次注射,患者112例,B组选择促性腺激素150IU,每日两次注射,患者68例,比较两组患者的临床结局。结果:(1)两组组患者的年龄、基础FSH、卵泡储备等比较差异均无统计学意义(P>0.05)。两组促排时间,卵子受精率、可利用胚胎率无统计学意义(P>0.05)。(2)两组HCG日雌激素浓度、HCG日卵泡直径>16mm的数量、获卵数及可利用胚胎数比较,差异有统计学意义(P<0.05)。(3)新鲜胚胎移植后,胚胎着床率、临床妊娠率及活产率无明显差异。结论:接受体外受精-胚胎移植卵巢低反应患者促性腺激素150IU两次给药和300IU单次给药比较,可以获得更多的卵母细胞和可利用胚胎,胚胎着床率、临床妊娠率及活产率无明显差异。Objective:To investigate the effects of gonadotropin administration on the clinical outcome of patients with ovarian hyporesponsiveness.Methods:Patients with low ovarian response who received routine in vitro fertilization and embryo transfer were divided into groups according to different times of medication.112 patients in group A were injected with gonadotropin once A day,each time 300IU.In group B,68 patients were injected with gonadotropin twice a day,each time 150IU.The clinical outcomes of the two groups were compared.Results:There was no significant difference in age,basal FSH and follicular reserve between the two groups(P>0.05).There was no significant difference in ovum fertilization rate and available embryo rate between the two groups(P>0.05).There were statistically significant differences between the two groups in the concentration of estrogen,the number of follicles>16 mm in diameter,the number of eggs obtained and the number of available embryos(P<0.05).After fresh embryo transplantation,there was no significant difference in embryo implantation rate,clinical pregnancy rate and live birth rate(P>0.05).Conclusion:Gonadotropin injection of 150IU twice daily in patients with low response to in vitro fertilization-embryo transfer(iv-ed)can obtain more oocytes and viable embryos,but has little effect on embryo implantation rate,clinical pregnancy rate and live birth rate.

关 键 词：卵巢低反应 促性腺激素 果纳芬 控制性卵巢刺激 

分 类 号：R322.65[医药卫生—人体解剖和组织胚胎学]