“双固一通”温针灸治疗膝骨性关节炎疗效观察及对血清炎性因子表达的影响  

Observation of Curative Efficacy of “Shuanggu Yitong” Warm Acupuncture and Moxibustion in Treatment of Knee Osteoarthritis and Its Effect on Expression of Serum Inflammatory Factors

作　　者：苏丹萍 宋玉娟 王雪冰 刘剑 黄维 SU Danping;SONG Yujuan;WANG Xuebing;LIU Jian;HUANG Wei(Department of Rehabilitation Medicine,The Central Hospital of Longhua District,Shenzhen 518110,China)

机构地区：[1]深圳市龙华区中心医院康复医学科,广东深圳518110

出　　处：《山东中医杂志》2020年第4期378-381,共4页Shandong Journal of Traditional Chinese Medicine

摘　　要：目的:探讨"双固一通"温针灸治疗膝骨性关节炎(KOA)的临床疗效及作用机制。方法:选取KOA患者90例,随机分为观察组和对照组各45例,对照组口服双氯芬酸钠缓释片治疗,观察组给予"双固一通"温针灸法治疗,观察并比较两组患者治疗前后膝关节功能、血清炎性因子水平,评定临床疗效。结果:治疗后观察组疼痛评分、关节僵硬评分、日常生活评分及总分均低于对照组(P<0.01);血清转化生长因子β(TGF-β)、胰岛素样生长因子-1(IGF-1)、成纤维细胞生长因子-2(FGF-2)水平均高于对照组(P<0.01),治疗愈显率高于对照组(P<0.05)。结论:"双固一通"温针灸法可有效改善KOA患者膝关节功能,抑制炎症反应,疗效显著。Objective:To investigate the curative efficacy of "Shuanggu Yitong" warm acupuncture and mox ibustion in the treatment of knee osteoarthritis(KOA) and its mechanism. Methods:A total of 90 patients with KOA were selected as the study subjects and randomly divided into the observation group and the control group,with 45 cases in each group. The control group was treated with oral diclofenac sodium sustained release tablets. The observation group was given Shuanggu Yitong warm acupuncture and moxibustion therapy. The function of the knee joint,the level of serum inflammatory factors before and after treatment and the clinical curative efficacy of the two groups were observed and compared. Results:After treatment,the pain score,joint stiffness score,daily life score and total score of the observation group were significantly lower than those of the control group(P<0.01). The serum levels of TGF-β,IGF-1 and FGF-2 of the observation group were significantly higher than those of the control group(P<0.01). The cure and marked effective rate of the treatment group was higher than that of the control group(P<0.05). Conclusion:"Shuanggu Yitong" warm acupuncture and moxibustion can effectively improve the knee joint function,inhibit the inflammatory reaction and its curative efficacy in the treatment of knee osteoarthritis is significant.

关 键 词：温针灸 膝骨性关节炎 膝关节功能 炎性因子 关元穴 足三里 阳陵泉 内膝眼 犊鼻 

分 类 号：R245.31[医药卫生—针灸推拿学] R274.9[医药卫生—中医临床基础]