雷公藤对慢性肾功不全患者肾功能保护及安全性分析  

作　　者：王辉[1] 张旭环[1] 曹津[1] 严倪 李媛[1] 

机构地区：[1]武警浙江省总队嘉兴医院,314000

出　　处：《浙江临床医学》2020年第1期51-53,共3页Zhejiang Clinical Medical Journal

基　　金：浙江省医学会临床科研项目(A2018ZYC-95)。

摘　　要：目的探讨雷公藤对慢性肾功不全患者肾功能保护作用及安全性.方法选取2014年1月至2017年1月慢性肾功不全患者198例.按照随机数表法分为2组,对照组98例,给予常规药物治疗,观察组100例,在常规治疗基础上给予雷公藤联合治疗.观察比较两组患者治疗后临床疗效,不良反应发生率及治疗前后两组患者24h尿蛋白定量(24hUprV),肌酐清除率(Ccr),血清肌酐(Scr),血尿素氮(BUN)水平及白细胞介素-6(IL-6)、单核细胞趋化蛋白-1(MCP-1)水平情况.结果治疗后,观察组患者总有效率(92.00%)明显高于对照组(77.55%)(P<0.05).观察组24hUprV,Scr,BUN水平明显低于对照组,Ccr水平明显高于对照组(P<0.05).观察组尿IL-6、MCP-1水平明显低于对照组(P<0.05).两组患者治疗后不良反应发生率比较无差异(P>0.05).结论雷公藤应用于慢性肾功不全患者临床疗效显著,对其肾功能保护具有积极意义,可抑制炎症因子IL-6、MCP-1水平,安全性高,值得临床推广应用.Objective To explore the protective effect and safety of Tripterygium wilfordii on renal function in patients with chronic renal insufficiency.Methods 198 patients with chronic renal insufficiency admitted to our hospital from January 2014 to January 2017 were selected.According to the random number table method,all the patients were divided into two groups,of which 98 cases in the control group were treated with conventional medicine,and 100 cases in the observation group were given the combined treatment of Tripterygium wilfordii on the basis of routine treatment.The clinical effect,the incidence of adverse reaction and the renal function 24h urine protein quantitative(24hUprV),creatinine clearance rate(Ccr),serum creatinine(Scr),blood urea nitrogen(BUN)level,interleukin-6(IL-6)and monocyte chemoattractant protein-1(MCP-1)level were compared between the two groups of patients before and after treatment.Results The total effective rate of the observation group after treatment(92%)was significantly higher than that of the control group(77.55%)(P<0.05).After treatment,the level of 24hUprV,Scr,BUN in the observation group was significantly lower than that of the control group,and the level of Ccr was significantly higher than that of the control group(P<0.05).After treatment,the levels of IL-6 and MCP-1 in the observation group were significantly lower than those in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups after treatment(P>0.05).Conclusion The clinical efficacy of Tripterygium Wilfordii in the patients with chronic renal insufficiency is significant and has positive significance to the protection of renal function.It can inhibit the level of inflammatory factors IL-6 and MCP-1,and it is highly safe and worthy of clinical application.

关 键 词：雷公藤 慢性肾功不全 肾功能保护 安全性 

分 类 号：R28[医药卫生—中药学]