丙种球蛋白治疗川崎病发生寒战的影响因素分析  

Analysis of influencing factors of chills in the treatment of Kawasaki disease with gamma globulin

作　　者：张金环[1] 王鹤[1] 徐德丽[1] Zhang Jinhuan;Wang He;Xu Deli(Department of Pharmacy,Weifang Maternal and Child Health Hospital,Weifang 261011,China)

机构地区：[1]潍坊市妇幼保健院药剂科,261011

出　　处：《国际医药卫生导报》2020年第5期689-691,共3页International Medicine and Health Guidance News

摘　　要：目的研究丙种球蛋白治疗川崎病发生寒战的影响因素。方法采用回顾性分析方法,收集本院于2017年12月至2019年1月收治的78例川崎病患儿临床资料,所有患儿均行丙种球蛋白治疗,将发生寒战的患儿纳入寒战组,将未发生寒战的患儿纳入非寒战组,了解所有患儿的一般资料,分析丙种球蛋白治疗川崎病发生寒战的影响因素。结果经统计发现,发生寒战患儿23例,主要集中于丙种球蛋治疗5 min^2 h之间,持续时间在10~50 min,主要表现为全身肌肉痉挛性发抖或不可控收缩。与非寒战组相比,寒战组年龄<3岁、体质量<10 kg、有血液制品过敏史、注射前体温大于38.5℃以及未调整至常温比例较高,差异有统计学意义(P<0.05)。经logistic多因素分析,年龄<3岁、体质量<10 kg、有血液制品过敏史、注射前体温大于38.5℃以及未调整至常温是发生寒战的危险因素(OR>1,P<0.05)。结论年龄<3岁、体质量<10 kg、有血液制品过敏史、注射前体温>38.5℃以及未调整至常温均可能增加丙种球蛋白治疗过程中发生寒战的风险,故临床治疗时应仔细询问患儿病史,且治疗期间,应注意丙种球蛋白的滴注速度和保暖,从而预防或减少寒战的发生。Objective To study the influencing factors of chills in the treatment of Kawasaki disease with gamma globulin.Methods The clinical data of 78 children with Kawasaki disease treated in our hospital from December 2017 to January 2019 were collected retrospectively.All the children were treated with gamma globulin.The children with chills were included in the chills group and the children without chills were included in the non-chills group.The general data of all the children were analyzed,and the influencing factors of chills in the treatment of Kawasaki disease with gamma globulin were analyzed.Results 23 cases of chills were found,which mainly focused on 5 min-2 h after the treatment with gamma globulin,with the time of duration of 10-50 min,the main manifestation was whole body muscle spasmodic trembling or uncontrollable contraction.The rates of age<3 years old,body mass<10 kg,history of allergy to blood products,body temperature greater than 38.5℃before injection,injection unadjusted to room temperature in the chills group were higher than those in the non-chills group(P<0.05).Logistic multivariate analysis showed that age<3 years old,body mass<10 kg,history of allergy to blood products,body temperature greater than 38.5℃before injection,injection unadjusted to room temperature were the risk factors of chills(OR>1,P<0.05).Conclusions Age<3 years old,body mass<10 kg,history of allergy to blood products,body temperature greater than 38.5℃before injection,injection unadjusted to room temperature may increase the risk of chills in the course of treatment with gamma globulin.Therefore,the medical history of children should be carefully asked during clinical treatment,and attention should be paid to the drip speed and warmth of gamma globulin during treatment,so as to prevent or reduce the occurrence of chills.

关 键 词：川崎病 丙种球蛋白 寒战 影响因素 

分 类 号：R72[医药卫生—儿科]