甲状腺结节微波消融术后体温及炎性指标变化规律及其意义  

Changes and significances of body temperature and inflammatory indexes after microwave ablation of thyroid nodules

作　　者：霍胜男 尹琳[2] 彭丽丽[2] 于明安[2] 赵朕龙 HUO Shengnan;YIN Lin;PENG Lili;YU Ming'an;ZHAO Zhenlong(Department of Thyroid,Hebei Handan Iron and Steel Group Co.,Ltd.Staff and Workers Hospital,Handan 056001,China;Department of Interventional Ultrasound,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]邯郸钢铁集团有限责任公司职工医院甲状腺科,河北邯郸056001 [2]中日友好医院介入超声医学科,北京100029

出　　处：《中国介入影像与治疗学》2020年第3期141-144,共4页Chinese Journal of Interventional Imaging and Therapy

基　　金：首都临床特色应用研究项目(Z181100001718135);北京化工大学-中日友好医院生物医学转化工程研究中心2018年度联合基金项目(PYBZ1804)。

摘　　要：目的观察微波消融(MWA)治疗甲状腺结节后患者体温及炎性指标变化,并探讨其意义。方法选取93例接受MWA治疗的甲状腺结节患者(160枚结节)。测量消融前及消融后30 min、12 h、24 h及48 h时腋下体温;于消融前及消融后24 h检测白细胞(WBC)、中性粒细胞百分比(NEU%)、红细胞沉降率(ESR)、C反应蛋白(CRP)、白细胞介素-1(IL-1)、IL-2、IL-6、IL-8及肿瘤坏死因子(TNF)水平。结果93例均一次性完全消融,消融时间60~862 s,平均(259.11±209.85)s。消融前后各时间点腋下体温总体比较差异无统计学意义(F=0.384,P=0.820)。消融后24 h,患者WBC、IL-6、IL-8、TNF均高于消融前(P均<0.05),消融前后NEU%、ESR、CRP、IL-1、IL-2差异无统计学意义(P均>0.05)。结论MWA治疗甲状腺结节可引起部分炎性因子改变,但程度较轻,术后患者体温轻微波动。Objective To observe the changes and significances of temperature and inflammatory factors after microwave ablation(MWA)of thyroid nodules.Methods A total of 93 cases with 160 thyroid nodules treated by MWA were enrolled.Axillary temperature was recorded before and 30 min,12 h,24 h,48 h after MWA.White blood cell(WBC),neutrophile percentage(NEU%),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),interleukin-1(IL-1),IL-2,IL-6,IL-8 and tumor necrosis factor(TNF)were tested before and 24 h after MWA.Results All 93 cases underwent complete ablation at one time,with a duration of 60-862 s and average of(259.11±209.85)s.There was no significant difference of armpit temperatures before and after ablation(F=0.384,P=0.820).WBC,IL-6,IL-8 and TNF 24 h after ablation were higher than before ablation(all P<0.05),and there was no statistically significant differences in NEU%,ESR nor CRP,IL-1,IL-2 before and after ablation(all P>0.05).Conclusion MWA of thyroid nodules can lead to slight changes of some inflammatory factors,but the patient's which cause only slight fluctuation of body temperature fluctuate slightly.

关 键 词：甲状腺结节 体温 炎性因子 微波消融 

分 类 号：R581[医药卫生—内分泌] R815[医药卫生—内科学]