Ir/Phase-Transfer-Catalysis Cooperatively Catalyzed Asymmetric Cascade Allylation/2-aza-Cope Rearrangement: An Efficient Route to Homoallylic Amines from Aldimine Esters  

作　　者：Liang Wei Lu Xiao Zuo-Fei Wang Hai-Yan Tao Chun-Jiang Wang 

机构地区：[1]College of Chemistry and Molecular Sciences,Wuhan University,Wuhan,Hubei 430072,China [2]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Shanghai 230021,China

出　　处：《Chinese Journal of Chemistry》2020年第1期82-86,共5页中国化学（英文版）

基　　金：This work was supported by NSFC(Nos.21525207,21772147);China Postdoctoral Science Foundation funded project(No.2017M620331).The Program of Introducing Talents of Discipline to Universities of China(111 Program)is also appreciated.We thank Prof.Shu-Li You at Shanghai Institute of Organic Chemistry(SIOC)for generously providing ligand THQPhos.

摘　　要：Summaryof main observation and conclusion Herein,we developed an Ir/phase-transfer-catalysiscooperatively catalyzed asymmetric cascade allyla-tion/2-aza-Cope rearrangement of aldimine esters to prepare synthetically important homoallylic amines in good yields with excellent enantioselectivi-ties.Compared with the bimetallic catalytic system to realize this transformation,the current cooperative Ir/tetrabutyl ammonium bromide catalytic system provides an alternative but more practical approach,which not only simplify the manipulation process but also increase the cost efficiency.

关 键 词：system simplify CATALYSIS 

分 类 号：O62[理学—有机化学]