益气养血活血方联合长春地辛治疗难治性血小板减少症的疗效及对IL-17、IL-21表达的影响  

Effect of Yiqi Yangxue Huoxue Recipe Combined with Vindesine in Treatment of Refractory Thrombocytopenia and Its Effect on Expressions of IL-17 and IL-21

作　　者：李琦[1] 范凌[1] 佟长青[1] 李亚军[1] LI Qi;FAN Ling;TONG Changqing;LI Yajun(Department of Hematology,The First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,Hebei,China)

机构地区：[1]河北北方学院附属第一医院血液内科,河北张家口075000

出　　处：《中华中医药学刊》2020年第1期240-244,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：河北省医学科学研究重点项目(20180875)。

摘　　要：目的探讨益气养血活血方联合长春地辛治疗难治性血小板减少症的疗效及对白细胞介素-17(IL-17)、白细胞介素-21(IL-21)表达的影响。方法难治性血小板减少症患者64例按照随机数字的方法分为两组,对照组和观察组,每组32例,对照组给予长春地辛,观察组在对照组治疗方案基础上使用益气养血活血方,两组治疗前后的主要症候积分进行比较,两组治疗前后的血小板计数,血小板平均体积进行比较,对两组治疗前后的IL-17、IL-21的水平进行比较,对两组的治疗效果进行对比,对两组在完成治疗后3个月的复发情况进行比较。结果经过治疗后,对照组的"神疲乏力"症状积分从(4.23±1.03)分降低到(1.38±0.31)分,"气短懒言"症状积分从(4.15±0.87)分降低到(1.35±0.22)分,"头晕目眩"症状积分从(3.98±0.81)分降低到(1.27±0.33)分,"面色苍白"症状积分从(3.81±0.71)分降低到(1.03±0.33)分,观察组的"神疲乏力"症状积分从(4.22±1.02)分降低到(0.74±0.23)分,"气短懒言"症状积分从(4.21±0.91)分降低到(0.77±0.13)分,"头晕目眩"症状积分从(3.91±0.78)分降低到(0.79±0.15)分,"面色苍白"症状积分从(3.77±0.82)分降低到(0.67±0.11)分,观察组的降低幅度大于对照组,数据差异均具有统计学意义(t=9.379,12.839,7.491,5.854,P<0.05),经过治疗后,对照组的血小板计数从(29.81±3.73)×10^9/L升高到(42.32±4.61)×10^9/L,血小板平均体积从(16.23±2.71)fL降低到(11.27±1.98)fL,观察组的血小板计数从(29.73±3.82)×10^9/L升高到(65.67±7.51)×10^9/L,血小板平均体积从(16.31±2.98)fL降低到(6.87±0.87)fL,观察组的变化幅度大于对照组,数据差异均具有统计学意义(t=-14.989,11.509,P<0.05),经过治疗后,对照组的IL-17从(19.64±3.21)pg/mL降低到(17.21±3.07)pg/mL,IL-21从(879.63±142.36)pg/mL降低到(687.51±122.67)pg/mL,观察组的IL-17从(19.78±3.17)pg/mL降低到(13.21±2.76)pg/mL,IL-21从(887.91±137.81)pg/mL降低到(493.35±100.8Objective To investigate the effect of Yiqi Yangxue Huoxue Recipe combined with vindesine in the treatment of refractory thrombocytopenia and its effect on the expression of interleukin-17(IL-17)and interleukin-21(IL-21).Methods According to the method of random numbers,Sixty-four patients with refractory thrombocytopenia were divided into a control group and an observation group,with 32 in each group.The control group was given vindesine,and the observation group used Yiqi Yangxue Huoxue Recipe on the basis of the treatment plan of the control group.The main symptom scores of the two groups before and after treatment were compared.Platelet counts and mean platelet volumes were compared between the two groups before and after treatment.The levels of IL-17 and IL-21 before and after treatment were compared between the two groups.The treatment effects of the two groups of patients were compared.The recurrence between the two groups 3 months after treatment was compared.Results After treatment,the"spirit fatigue"symptom score of the control group decreased from(4.23±1.03)points to(1.38±0.31)points,the"shortness of breath"syndrome score decreased from(4.15±0.87)points to(1.35±0.22)points,the"shot dizziness"symptom score decreased from(3.98±0.81)points to(1.27±0.33)points,and the"pale pale"symptom score decreased from(3.81±0.71)points to(1.03±0.33)points.In the observation group,the"spirit fatigue"symptom score decreased from(4.22±1.02)points to(0.74±0.23)points,and the"shortness of breath"syndrome score decreased from(4.21±0.91)points to(0.77±0.13)points.The"dizziness"symptom score decreased from(3.91±0.78)points to(0.79±0.15)points,and the"pale pale"symptom score decreased from(3.77±0.82)points to(0.67±0.11)points.The reduction of the observation group was greater than that of the control group,and the data was statistically significant(t=9.379,12.839,7.491,5.854,P<0.05).After treatment,the platelet count of the control group increased from(29.81±3.73)×10^9/L to(42.32±4.61)×10^9/L,and the average

关 键 词：益气养血活血方 长春地辛 血小板减少症 

分 类 号：R558.2[医药卫生—血液循环系统疾病]