血浆置换与去白细胞红细胞悬液输血治疗混合抗体型自身免疫性溶血性贫血的效果  

Effects of plasma exchange and leukocyte-reduced erythrocyte suspension transfusion on mixed antibody autoimmune hemolytic anemia

作　　者：钟胜英 ZHONG Shengying(Department of Blood Transfusion OF Xingning People’s Hospital,Meizhou 514500 Guangdong,China)

机构地区：[1]广东省梅州市兴宁市人民医院输血科,广东梅州514500

出　　处：《中国民康医学》2020年第3期6-8,共3页Medical Journal of Chinese People’s Health

基　　金：梅州市医药卫生科研课题(2018-B-66)。

摘　　要：目的:比较血浆置换与去白细胞红细胞悬液输血治疗混合抗体型自身免疫性溶血性贫血(AIHA)患者的效果。方法:选取100例混合抗体型AIHA患者作为研究对象,根据不同治疗方法分为研究组和对照组,每组50例。研究组予去白细胞红细胞悬液输血治疗,对照组予血浆置换治疗,比较两组临床疗效,治疗前后临床相关指标水平,输血情况及不良反应发生率。结果:治疗后,研究组治疗总有效率为98.00%,高于对照组的94.00%,差异无统计学意义(P>0.05);研究组血红蛋白(Hb)、红细胞计数(RBC)水平高于对照组,网织红细胞、胆红素水平低于对照组,差异有统计学意义(P<0.05);研究组输血次数与输血总量均少于或低于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率为2.00%,低于对照组的18.00%,差异有统计学意义(P<0.05)。结论:去白细胞红细胞悬液输血与血浆置换治疗AIHA患者效果相似,但去白细胞红细胞悬液输血更利于改善患者临床相关指标水平,且安全性较高。Objective:To compare effects of plasma exchange and leukocyte-reduced erythrocyte suspension transfusion on mixed antibody autoimmune hemolytic anemia(AIHA).Methods:100 patients with mixed antibody type AIHA were selected as the research objects,and were divided into study group and control group according to different treatment methods,50 cases in each group.The study group was treated with leukocyte-reduced erythrocyte suspension transfusion,while the control group was treated with plasma exchange.The clinical efficacy,clinical indicators before and after the treatment,blood transfusion,and incidence of adverse reactions were compared between the two groups.Results:After the treatment,the total effective rate in the study group was 98.00%,which was higher than 94.00%in the control group,and the difference was not statistically significant(P>0.05).The levels of hemoglobin(Hb)and red blood cell(RBC)in the study group were higher than those in the control group;the levels of reticulocyte and bilirubin were lower than those in the control group;and the differences were statistically significant(P<0.05).The number of blood transfusions and the total blood transfusion in the study group were smaller or less than those in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was 2.00%,which was lower than 18.00%in the control group,and the difference was statistically significant(P<0.05).Conclusions:Leukocyte-reduced erythrocyte suspension transfusion and erythrocyte suspension have similar effects in the treatment of the patients with AIHA.However,the former is more beneficial to improving the levels of clinically relevant indicators with higher safety.

关 键 词：去白细胞红细胞悬液 血浆置换 混合抗体型 自身免疫性溶血性贫血 输血 

分 类 号：R556.6[医药卫生—血液循环系统疾病]