低剂量米非司酮联合去氧孕烯炔雌醇治疗无排卵型功血的临床效果与安全性观察  

Clinical effects and safety of low-dose Mifepristone combined with Desogestrel and Ethinylestradiol in treatment of anovulatory functional bleeding

作　　者：宋秀玲 葛静 杨楠 SONG Xiuling;GE Jing;YANG Nan(Department of Obstetrics and Gynecology of Northern China General Hospital,Shenyang 110016 Liaoning,China)

机构地区：[1]北部战区总医院妇产科,辽宁沈阳110016

出　　处：《中国民康医学》2020年第3期22-24,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察低剂量米非司酮联合去氧孕烯炔雌醇治疗无排卵型功能失调性子宫出血的临床效果与安全性。方法:选取80例无排卵型功血患者作为研究对象,采用随机数字表法分为对照组与观察组各40例,对照组给予低剂量米非司酮治疗,观察组给予低剂量米非司酮联合去氧孕烯炔雌醇治疗,比较两组治疗后的止血时间、月经量失血图(PBAC)评分、性激素水平及不良反应发生率。结果:治疗后,观察组止血时间明显短于对照组,差异有统计学意义(P<0.05);观察组PBAC评分明显低于对照组,差异有统计学意义(P<0.05);治疗前,两组卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E2)、孕酮(P)水平比较,差异无统计学意义(P>0.05),治疗后,两组FSH、LH、E2、P水平均明显降低,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论:采用低剂量米非司酮联合去氧孕烯炔雌醇治疗无排卵型功血效果可靠,能有效纠正患者性激素水平,缩短止血时间,且安全性好。Objective:To investigate clinical effects and safety of low-dose Mifepristone combined with Desogestrel and Ethinylestradiol in treatment of anovulatory dysfunctional uterine bleeding.Methods:80 patients with anovulatory functional bleeding were selected as the research objects,and were divided into control group and observation group by using the random number table method,40 cases in each.The control group was given low-dose Mifepristone,while the observation group was given low-dose Mifepristone combined with Desogestrel and Ethinylestradiol.The hemostatic time,pictorial blood loss assessment chart(PBAC)score,sex hormone levels and incidence of adverse reactions were compared between the two groups after the treatment.Results:The hemostatic time in the observation group was significantly shorter than that in the control group after the treatment,and the difference was statistically significant(P<0.05).After the treatment,the PBAC score in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Before the treatment,there were no significant differences in the levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),and progesterone(P)between the two groups(P>0.05).However,after the treatment,the levels of FSH,LH,E2,and P in the two groups decreased significantly;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusions:lowdose Mifepristone combined with Desogestrel and Ethinylestradiol is reliable in the treatment of anovulatory dysfunctional uterine bleeding.It can effectively correct the level of sex hormones and significantly reduce the hemostatic time with high safety.

关 键 词：低剂量米非司酮 去氧孕烯炔雌醇 无排卵型功血 临床效果 

分 类 号：R711.52[医药卫生—妇产科学]