60例产后抑郁症和催乳素、雌二醇、孕酮之间的相关性分析  

Correlation analysis between 60 cases of postpartum depression and prolactin,estradiol and progesterone

作　　者：梁新星 彭敬红[2] LIANG Xin-xing;PENG Jing-hong(Xinqiao Town Community Health Service Center,Songjiang District,Shanghai 201600)

机构地区：[1]上海市松江区新桥镇社区卫生服务中心检验科,上海201600 [2]上海交通大学附属第一人民医院松江分院检验科,上海201600

出　　处：《医学检验与临床》2019年第10期18-20,共3页Medical Laboratory Science and Clinics

摘　　要：目的:探讨产后抑郁症和PRL、E2、P之间的相关性.方法:回顾性分析2017年3月~2018月12月,上海市交通大学附属第一人民医院松江分院收治的297例初产妇,使用爱丁堡产后抑郁量表(EPDS)评分,分为观察组即产后抑郁组60例,非产后抑郁症237例为对照组,使用电化学发光法检测两组产前、产后2d、产后7d血清催乳素、雌二醇、孕酮含量.结果:产后抑郁症发生率为20.2%.产后抑郁症在各时间点的EPDS评分均显著大于对照组,差异有统计学意义(P<0.05).产前,两组患者催乳素、雌二醇、孕酮水平差异均无统计学意义(P>0.05);产后7d的E2,PRL和P水平与产后2d相比,差异有统计学意义(P<0.05);观察组的产后2d和产后7d的E2,PRL和P水平与对照组相比,差异有统计学意义(P<0.05).Pearson相关分析显示,产后EPDS评分与产后7d催乳素、孕酮呈正相关(r=0.487,r=0.409,P<0.05),与雌二醇呈负相关(r=-0.583,P<0.05).结论:分娩后雌二醇下降速度过快,或催乳素、孕酮下降速度过慢是产后抑郁症发生的危险因素,检测产后2d、产后7d血清催乳素、雌二醇、孕酮含量对预测产后抑郁症的发生有重要意义.Objective:To investigate the correlation between postpartum depression and prolactin,estradiol and progesterone.Methods:A retrospective analysis of 297 primiparas admitted to the Songjiang Branch of the First People's Hospital of Shanghai Jiaotong University from March 2017 to December 2018,using the Edinburgh Postnatal Depression Scale(EPDS)on the 2nd and 7th day after delivery.In the observarion group,60 patients with postpartum depression,EPDS≥13;237 patients with non—postpartum depression were control group,EPDS<13 points.The levels of serum prolactin,estradiol and progesterone were measured by electrochemiluminescence method before and after 2 days postpartum and 7 days postpartum.Results:The incidence of postpartum depression was 20.0%.The EPDS scores of postpartum depression were significandy higher than those of the control group at each time point,and the difference was statistically significant(P<0.05).There was no significant difference in prolacrin,estradiol and progesterone levels between the two groups(P>0.05).There was a statistically significant difference between the E2,PRL and P levels at 7 days postpartum and postpartum 2 days.<0.05);The E2,PRL and P levels in the observarion group at 2 days postpartum and 7 days postpartum were significantly different from those in the control group(P<0.05).Pearson correlation analysis showed that postpartum EPDS score was positively correlated with prolactin and progesterone at 7 days postpartum(r=0.487,r=0.409,P<0.05),and negatively correlated with estradiol(r=-0.583,P<0.05).Conclusion:The rate of estradiol decline after delivery is too fast,or the slow rate of prolactin and progesterone decline is a risk factor for postpartum depression.Serum prolactin,estradiol and progesterone levels are measured postpartum 2d postpartum and 7d postpartum.The occurrence of depression is of great significance.

关 键 词：产后抑郁症 催乳素 雌二醇 孕酮 

分 类 号：R71[医药卫生—妇产科学]