青蒿素和胺碘酮对大鼠心律失常作用的对比研究  

Comparison of effects between artemisinin and amiodarone on rat arrhythmia

作　　者：李敏 张乐曙 周洁茹 张倩 张家伟 董薇 LI Min;ZHANG Leshu;ZHOU Jieru;ZHANG Qian;ZHANG Jiawei;DONG Wei(Grade 15,First Faculty of Clinical Medicine,Xuzhou Medical University,Xuzhou,Jiangsu 210002,China;National Experimental Teaching Demonstration Center of Basic Medicine,Xuzhou Medical University,Xuzhou,Jiangsu 210002,China)

机构地区：[1]徐州医科大学第一临床医学系,江苏徐州210002 [2]徐州医科大学国家级基础医学实验教学示范中心,江苏徐州210002

出　　处：《重庆医学》2020年第6期883-886,共4页Chongqing medicine

基　　金：江苏高校品牌专业项目(201810313066X)。

摘　　要：目的比较青蒿素和胺碘酮对大鼠心律失常的作用效果。方法采用氯化钡诱导大鼠心律失常模型,观察青蒿素和胺碘酮对大鼠QT间期和QRS间期的影响,并以Lorenz散点图的方式观察心电图的变化。结果5.0、10.0、20.0 mg/kg青蒿素组心电图中心律失常开始的时间分别为(3.3±1.2)、(4.5±1.2)、(6.5±1.1)min,心律失常的治疗效果呈剂量依赖性,20.0 mg/kg组效果最好;5.0、20.0 mg/kg青蒿素组可明显缩短QT间期,尤以20.0 mg/kg青蒿素组第6分钟时最为明显(P<0.05)。Lorenz散点图形态分布中,胺碘酮组短棒状占33.3%,5.0、10.0、20.0 mg/kg青蒿素组短棒状分别占50.0%、44.4%、63.6%。结论青蒿素抗心律失常的疗效呈剂量依赖性,大剂量时缩短大鼠QT间期的效果优于胺碘酮,且不良反应小。Objective To compare the effects of artemisinin and amiodarone on rat arrhythmia.Methods The rat arrhythmia model induced by barium chloride was adopted.The effects of artemisinin and amiodarone on QT interval and QRS interval in rats were observed and compared.The changes of ECG were observed by using the Lorenz scatter diagram.Results The beginning time of arrhythmia in ECG in the artemisinin 5.0,10.0,20.0 mg/kg groups was(3.3±1.2)min,(4.5±1.2)min and(6.5±1.1)min respectively,the enhancement of the effect was dose-dependent,and which in the 20.0 mg/kg group was better.The QT interval was significantly shortened in the artemisinin 5.0 mg/kg and 20.0 mg/kg groups,especially which at 6 min in the 20.0 mg/kg group was most significant(P<0.05).In the morphological distribution of Lorenz scatter plots,the short bars in the amiodarone group accounted for 33.3%,while those in the artemisinin 5.0,10.0 and 20.0 mg/kg groups accounted for 50.0%,44.4%and 63.6%respectively.Conclusion Artemisinin shows a dose-dependent effect,and the effect of shortening QT interval in rats at large dose is better than that of amiodarone,moreover the toxicity and side effects are lower.

关 键 词：青蒿素 胺碘酮 抗心律失常 BL-420F生物机能实验系统 

分 类 号：R965.3[医药卫生—药理学]