围绝经期女性冠脉病变程度与非高密度脂蛋白水平相关性  

Correlation between coronary artery lesions and non-high density lipoprotein cholesterol levels in perimenopausal women

作　　者：孙飞 仲鹏[2] 张文迪 朱晔 魏子秀[2] SUN Fei;ZHONG Peng;ZHANG Wendi;ZHU Ye;WEI Zixiu(School of Clinical Medicine,Jining Medical University,Jining 272013,China;Jining NO.1 People’s Hospital&the Affiliated Hospital of Jining Medical University,Jining 272011,China)

机构地区：[1]济宁医学院临床医学院,济宁272013 [2]济宁医学院附属济宁市第一人民医院,济宁272011

出　　处：《济宁医学院学报》2020年第1期36-39,43,共5页Journal of Jining Medical University

摘　　要：目的探讨非高密度脂蛋白胆固醇(non-HDL-C)水平与围绝经期女性冠脉严重程度相关性。方法收集2017年8月至2019年5月于济宁医学院附属济宁市第一人民医院住院行冠脉造影术并确诊为冠心病的40~60岁围绝经期女性患者69例作为研究对象,根据Gensini评分分为轻中度冠脉病变组(GS<50,n=42)及重度冠脉病变组(GS≥50,n=27),并收集患者的一般资料及相关化验检查,logistic回归分析重度冠心病的独立危险因素,ROC曲线评估non-HDL-C水平预测重度冠脉病变的最佳切点。结果重度冠脉病变组的nonHDL-C水平高于轻中度冠脉病变组(P<0.05);non-HDL-C可为该人群冠脉病变严重程度的独立危险因素(OR=4.223,P<0.001,95%CI:1.516~11.765);ROC曲线分析结果提示non-HDL-C预测重度冠脉病变的最佳切点为3.36mmol/L,灵敏度为96.3%,特异度为66.7%。结论non-HDL-C与围绝经期女性冠脉病变严重程度相关,non-HDL-C水平升高是重度冠脉病变的独立危险因素;当non-HDL-C>3.36mmol/L,可预测冠状动脉严重病变。Objective To investigate the correlation between non-HDL cholesterol(non-HDL-C) level and coronary severity in perimenopausal women.Methods A total of 69 female patients aged 40~60 years who were diagnosed with coronary heart disease and underwent coronary angiography in the First People s Hospital of Jining City from August 2017 to May 2019 were enrolled.According to the Gensini score patients in the observation group was divided into two groups.Patients with mild to moderate coronary lesions were in one group(GS <50,n=42) and patients with severe coronary lesions were in another group(GS≥50,n=27).Logistic regression was used to analyze independent risk factors for severe coronary heart disease.ROC curve was used to estimate the best cut point for severe coronary lesions.Results The level of non-HDL-C in the observation group was higher than that in the control group(P <0.001).The level of non-HDL-C in patients with severe coronary lesions was higher than that in Patients with mild to moderate coronary lesions(P <0.001).Non-HDL-C could be used as independent risk factor to evaluate severe coronary lesions(OR=4.223,P<0.001 95% CI:1.516~11.765).ROC curve analysis indicated that the best cut point for non-HDL-C prediction of severe coronary artery disease was 3.36 mmol/L.The sensitivity was 96.3% and the specificity was 66.7%.Conclusion Non-HDL-C is related to the severity of coronary lesions in perimenopausal women.The increase of non-HDL-C level is an independent risk factor for severe coronary artery disease.Non-HDL-C> 3.36 mmol/L can predict the possibility of severe coronary artery disease.

关 键 词：非高密度脂蛋白胆固醇 低密度脂蛋白 围绝经期女性 冠脉病变程度 GENSINI评分 

分 类 号：R541.4[医药卫生—心血管疾病]