白消安对睾丸的毒害作用及机制探讨  

Study on the Toxic Effect and Mechanism of Busulfan on Testis

作　　者：李茹意 MENGAL Kifayatullah 陈晓丽[1,2] 王栋 LI Ruyi;MENGAL Kifayatullah;CHEN Xiaoli;WANG Dong(Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing 100193,China;College of Animal Science and Technology,Jilin Agricultural University,Changchun 130118,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所,北京100193 [2]吉林农业大学动物科学技术学院,长春130118

出　　处：《畜牧兽医学报》2020年第3期426-432,共7页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金(31772595)。

摘　　要：白消安(busulfan)对精子发生具有较强毒害作用,可导致雄性不育,是制备精原干细胞(spermatogonial stem cells, SSCs)移植受体的理想药剂。睾丸炎对生精机能也有重要影响,甚至能导致雄性不育。然而,白消安损害血睾屏障(blood-testis barrier, BTB),影响精子发生的机制尚不清楚,尚不知其是否会导致非传染性睾丸炎症,并影响细胞因子分泌,损害生育能力。因此,本文综述了白消安对BTB的破坏作用、对睾丸细胞相关功能蛋白的影响,以及白消安损伤睾丸的缓解方法,以深入揭示白消安对睾丸细胞和BTB功能与结构的毒害作用,为研发高效安全的SSCs移植受体制备技术,以及化疗药物治疗和环境毒素作用下生精机能科学防护与恢复提供科学参考。Busulfan has high toxic effect on the spermatogenesis and can cause male sterility. It is an ideal agent for the preparation of transplant recipients of spermatogonial stem cells(SSCs). Orchitis also has an important effect on the spermatogenic function and can even lead to male sterility. However, the mechanism by which busulfan damages the blood-testis barrier(BTB) and affects spermatogenesis is unclear. It is unknown whether it will cause non-infectious testicular inflammation, affect cytokine secretion, and impair fertility. Therefore, the damage effect of busulfan on the BTB, its effects on testicular cell-related functional proteins, and the relief methods of busulfan-damaged testis are summerized in this review. It deeply reveals the toxic effect of busulfan on the function and structure of testicular cells and BTB. Furthermore, we provide theoretical guidance for the efficient and safe preparation of SSCs transplantation recipients, and protection and recovery of male spermatozoa under the action of therapeutic and environmental toxins.

关 键 词：白消安 血睾屏障 炎症 细胞因子 

分 类 号：S821.3[农业科学—畜牧学]