mHLA-G联合PCT、hs-CRP在肾移植排斥反应及感染中的诊断价值分析  

Analysis of diagnostic value of mHLA-G combined with PCT,hs-CRP in renal transplant rejection and infection

作　　者：申升[1] 朱春丽[1] 李琴[1] 周结学[1] 蒙善东[1] 马娟[1] 邓庚国 王晓[1] 刘东(指导)[1] SHEN Sheng;ZHU Chun-Li;LI Qin;ZHOU Jie-Xue;MENG Shan-Dong;MA Juan;DENG Geng-Guo;WANG Xiao;LIU Dong(Department of Organ Transplantation,Guangdong Second People′s Hospital,Guangzhou 510317,China)

机构地区：[1]广东省第二人民医院器官移植科,广州510317

出　　处：《中国免疫学杂志》2020年第6期739-743,共5页Chinese Journal of Immunology

基　　金：广州市科技计划项目(201707010366)。

摘　　要：目的:探讨膜型人类白细胞抗原(mHLA-G)联合血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)在肾移植排斥反应及感染中的诊断价值。方法:以我院2015年1月~2018年10月126例肾移植患者为研究对象,其中肾功能稳定组42例,术后发生急性排斥反应(AR)组40例,术后发生感染组44例,另选同期健康体检者50例作为正常对照组;对比4组外周血mHLA-G、血清PCT、hs-CRP水平,分析这些指标在肾移植排斥反应及感染中的诊断价值。结果:肾移植后4周,AR组mHLA-G表达水平最低,与稳定组、感染组、对照组相比差异均有明显统计学意义(P<0.05);感染组mHLA-G表达水平最高,明显高于对照组、稳定组、AR组(P<0.05);稳定组mHLA-G表达水平略低于对照组,但差异无统计学意义(P>0.05)。肾移植后4周,AR组血清PCT水平明显高于稳定组与对照组(P<0.05),但稳定组与对照组间无明显差异(P>0.05);感染组血清PCT水平明显高于AR组、稳定组、对照组(P<0.05)。肾移植后4周,AR组与感染组血清hs-CRP均明显高于稳定组与对照组(P<0.05),且AR组与感染组无明显差异(P>0.05)。mHLA-G联合PCT、hs-CRP与在肾移植排斥反应及感染中的诊断价值明显高于单一检测指标。结论:mHLA-G联合PCT、hs-CRP在肾移植AR及感染中具有重要诊断价值。Objective:To investigate the diagnostic value of membranous human leukocyte antigen(mHLA-G)combined with serum procalcitonin(PCT)and high-sensitivity C-reactive protein(hs-CRP)in renal allograft rejection and infection.Methods:In our hospital from Janurary 2015 to October 2018,126 kidney transplant patients were selected in the study,including 42 patients with stable renal function,40 patients with acute rejection(AR)after operation,and 44 patients with postoperative infection.Another 50 healthy subjects were selected as the normal control group.The levels of mHLA-G,serum PCT and hs-CRP in the peripheral blood of the 4 groups were compared.The diagnostic value of these indexes in renal transplant rejection and infection were analyzed.Results:4 weeks after kidney transplantation,the expression level of mHLA-G was the lowest in AR group,which was significantly different from that in stable group,infected group and control group(P<0.05).The expression level of mHLA-G was the highest in the infected group,which was significantly higher than that in the control group,the stable group and AR group(P<0.05).The expression level of mHLA-G in the stable group was slightly lower than that in the control group,but the difference was not statistically significant(P>0.05).4 weeks after kidney transplantation,the serum PCT level in the AR group was significantly higher than that in the stable group and the control group(P<0.05),but there was no significant difference between the stable group and the control group(P>0.05).The serum PCT level of the infected group was significantly higher than that of the AR group,stable group,control group(P<0.05).At 4th week after kidney transplantation,serum hs-CRP levels in AR group and infected group were significantly higher than those in stable group and control group(P<0.05),and there was no significant difference between AR group and infected group(P>0.05).The diagnostic value of mHLA-G combined with PCT,hs-CRP and renal allograft rejection and infection was significantly higher than tha

关 键 词：IL-2 PCT HS-CRP 肾移植 感染 诊断价值 

分 类 号：R441[医药卫生—诊断学]