冠状动脉粥样硬化斑块分布与危险因素的关系  

Relationship between plaque distribution and risk factors of coronary atherosclerosis

作　　者：耿校伦 曾自三[1] 许华 陈蔚蔚 管学春[1] 黄福灵[1] 李牡艳[5] Geng Xiaolun;Zeng Zisan;Xu Hua;Chen Weiwei;Guan Xuechun;Huang Fuling;Li Muyan(Department of Radiology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;Guangxi Key Laboratory of Regenerative Medicine,Nanning 530021,China;Research Center of Regenerative Medicine,Guangxi Medical University,Nanning 530021,China;Joint Laboratory of Bone and Soft Tissue Regeneration and Repair,Repair,Nanning 530021,China;Guangxi Collaborative Innovation Center for Biomedicine,Nanning 530021,China)

机构地区：[1]广西医科大学第一附属医院放射科,南宁530021 [2]广西再生医学重点实验室,南宁530021 [3]广西医科大学再生医学研究中心,南宁530021 [4]广西医科大学教育部骨与软组织再生修复联合实验室,南宁530021 [5]广西医科大学广西生物医药协同创新中心,南宁530021

出　　处：《广西医科大学学报》2020年第2期230-234,共5页Journal of Guangxi Medical University

基　　金：国家自然科学基金资助项目(No.03101216047D);广西再生医学重点实验室开放课题资助项目(No.桂再重开201804)。

摘　　要：目的:探讨冠状动脉粥样硬化斑块分布与危险因素之间的关系。方法:选取2018年1月至2018年12月在广西医科大学第一附属医院收治的740例疑似冠心病住院患者,并在此期间完成CT冠状动脉检查且有完整的临床资料。根据研究对象是否有相应支段的病变,分为右冠状动脉(RCA)病变组和非病变组,左冠状动脉主干(LM)病变组和非病变组,前降支(LAD)病变组和非病变组,回旋支(LCX)病变组和非病变组。并进行统计学分析。结果:斑块分布在4个支段的病变组中,病变组的年龄、男性、高血压和糖尿病比例均显著高于非病变组(P<0.05);斑块分布在RCA和LAD病变组的吸烟和低高密度脂蛋白(HDL-C)比例均高于非病变组(P<0.05);斑块分布在LM和LCX病变组的汉族比例高于非病变组(P<0.05)。其中性别、年龄与这4个支段病变的发生密切相关;高血压与RCA、LAD、LCX病变的发生密切相关;糖尿病与RCA、LCX病变的发生密切相关。结论:患者的年龄、性别、高血压、糖尿病、吸烟、低HDL-C等危险因素均对冠心病斑块的分布具有一定的影响,其中性别、年龄是这4支段病变的危险因素,高血压是RCA、LAD和LCX的危险因素,糖尿病是RCA和LCX的危险因素。Objective:To explore the relationship between plaque distribution and risk factors of coronary atherosclerosis.Methods:A total of 740 patients with suspected coronary artery disease who were admitted to the First Affiliated Hospital of Guangxi Medical University from January 2018 to December 2018 were selected as research subjects.During this period,the patients underwent CT coronary artery examination,and the complete clinical data were collected.According to whether they have atherosclerotic plaque in corresponding branches,the subjects were divided into right coronary artery(RCA)lesioned group and non-lesioned group,left main artery(LM)lesioned group and non-lesioned group,left anterior descending(LAD)lesioned group and non-lesioned group,and left circumflex artery(LCX)lesioned group and non-lesioned group.Subsequently,statistical analysis was carried out.Results:The proportion of elder,male,hypertension,and diabetes in the four lesioned groups were significantly higher than those in their corresponding non-lesion groups(P<0.05),respectively.The percentages of smoking and low high density lipoprotein cholesterol(HDL-C)level were higher in the ECA and LAD lesioned groups than those in their corresponding non-lesioned groups(P<0.05).The proportion of Hans in the LM and LCX lesioned groups was higher than that in their corresponding non-lesioned groups(P<0.05).Among these factors,gender and age were closely related to the occurrence of these four lesions;hypertension was closely related to the occurrence of RCA,LAD,and LCX lesions;diabetes was closely related to the occurrence of RCA and LCX lesions.Conclusion:Patients’age,gender,hypertension,diabetes,smoking,and low HDL-C level will affect the distribution of coronary artery disease plaques,among them,gender and age are the risk factors for these four branches,blood pressure is a risk factor for RCA,LAD,and LCX lesions,and diabetes is a risk factor for RCA and LCX lesions.

关 键 词：冠状动脉粥样硬化 斑块分布 危险因素 CT冠脉检查 

分 类 号：R541.4[医药卫生—心血管疾病]