蛋白质组学在骨科的应用现状  

Current application of proteomics in orthopaedic field

作　　者：刘鹤鸣[1] 刘海艳[2] 马晓峰[1] 杨增华[1] 王坤正[3] LIU He-ming;LIU Hai-yan;MA Xiao-feng;YANG Zenghua;WANG Kun-zheng(Department of Orthopaedics,The First Affiliated Hospital,Baotou Medical College,Baotou 014010,China;Department of Intervention Therapy,The First Affiliated Hospital,Baotou Medical College,Baotou 014010,China;Department of Orthopaedics,The Second Affiliated Hospital,Xi'an Jiaotong University,Xi’an 710004,China)

机构地区：[1]包头医学院第一附属医院骨科,内蒙古包头014010 [2]包头医学院第一附属医院介入科,内蒙古包头014010 [3]西安交通大学第二附属医院骨科,西安710004

出　　处：《中国矫形外科杂志》2020年第5期435-438,共4页Orthopedic Journal of China

基　　金：内蒙古自然科学基金项目(编号:2018MS08146);包头医学院科学研究基金项目(编号:BYJJ-YF 201730)。

摘　　要：蛋白质组学可以在蛋白质水平对各种生理、病理过程进行整体而全面的认识,近年来在医学领域得到广泛应用,本文就其在骨科的应用现状进行综述,包括股骨头坏死的病理机制研究、骨质疏松发生机制研究、骨肉瘤发生机制、早期诊断和治疗筛选研究、骨性关节炎生物标记物筛选和发生机制研究、类风湿关节炎发生机制研究、诊断和预后、脊髓损伤发生及修复机制研究、骨折愈合过程研究和骨折风险评估、椎间盘退变机制研究等。Proteomics can provide a comprehensive understanding of various physiological and pathological processes at the protein level. It has been widely used in the medical field in recent years. This article reviews the current application of proteomics in orthopedic researches, involving pathological mechanism of femoral head necrosis;mechanism of osteoporosis;pathogenesis, early stage diagnosis and treatment screening of osteosarcoma;biomarkers screening and mechanism of osteoarthritis;the mechanism, diagnosis and prognosis of rheumatoid arthritis;mechanism of spinal cord injury and repair;fracture healing process and fracture risk assessment, as well as mechanism of intervertebral disc degeneration.

关 键 词：蛋白质组学 骨科 诊断 发生机制 

分 类 号：R318[医药卫生—生物医学工程]