抗HPV生物蛋白敷料与重组人干扰素α-2b凝胶治疗高危型HPV感染的研究  

Treatment of high-risk HPV infection with Anti-HPV biological protein dressing and recombinant human interferonα-2b gel

作　　者：何晶 张烽 朱佳尔 HE Jing;ZHANG Feng;ZHU Jia-er(Wuxi Third People's Hospital,Wuxi,Jiangsu 214000,China)

机构地区：[1]江南大学附属医院(原无锡三院)妇产科,江苏无锡214000 [2]江南大学附属医院(原无锡三院)检验科,江苏无锡214000

出　　处：《中华医院感染学杂志》2020年第3期403-408,共6页Chinese Journal of Nosocomiology

基　　金：江苏省妇幼健康科研基金资助项目(F201741);无锡市卫生计生委科研基金资助项目(MS201723)。

摘　　要：目的分析高危型人乳头瘤病毒(Human papilloma virus,HPV)感染经生物蛋白敷料、重组人干扰素α-2b凝胶治疗的有效性与安全性,为高危型HPV感染的治疗提供参考。方法选取2016年4月-2018年4月无锡市第三人民医院收治的100例高危型HPV感染患者,根据随机数字表法分为对照组与研究组,各50例,确定患者HPV高危亚型及各项检查结果后,给予对照组重组人干扰素α-2b凝胶治疗,给予研究组抗HPV生物蛋白敷料治疗,连续治疗3个月经周期后,随访9个月。记录患者各项检查结果,包括HPV亚型、宫颈薄层液基细胞学(TCT)、阴道镜及病理检查等;分别于治疗结束时、治疗结束后3个月、6个月、9个月,检测并对比两组HPV转阴率;比较两组内、组间治疗前及最后一次随访各检查结果变化情况,治疗期间记录患者不良反应发生情况。结果100例患者经查HPV主要检出亚型包括16型、52型、58型,经TCT检查,超过90%未见上皮内细胞病变;经阴道镜检查,多为慢性宫颈炎或宫颈低级病变;经病理学检查,极少部分为CINⅠ级;治疗期间,两组不良反应发生率差异无统计学意义(P=0.646);治疗结束时,研究组HPV转阴率为16.00%(8/50),与对照组比较差异无统计学意义(P=0.218);治疗结束后3个月、6个月、9个月,两组HPV转阴率均较治疗结束时升高,且研究组各时点转阴率分别为30.00%(15/50)、50.00%(25/50)、60.00%(30/50)均高于对照组(P<0.05);治疗前后,两组组内、组间TCT检查结果和阴道镜检,差异无统计学意义;研究组治疗后无异常12.00%(6/50)高于治疗前(P=0.013);研究组6例接受宫颈病理检查,其中包括4例慢性宫颈炎,2例CINⅠ级;对照组8例中检出1例慢性宫颈炎、4例CINⅠ级、1例CINⅡ级、1例CINⅢ级及1例累及腺体。结论高危型HPV感染以16型、52型、58型为主,抗HPV生物蛋白敷料用于疾病的治疗获得的远期转阴率优于重组人干扰素α-2b凝胶,且使用期间无明OBJECTIVE To analyze the effectiveness and safety of anti-human papilloma virus(HPV)biological protein dressing and recombinant human interferonα-2 b gel in the treatment of high-risk HPV infection,so as to provide reference for reasonable treatment of high-risk HPV infection.METHODS Totally 100 patients with high-risk HPV infection admitted in Wuxi Third People’s Hospital from Apr.2016 to Apr.2018 were selected and divided into control group and research group by random number table,with 50 cases in each group.After determining the high-risk subtype of HPV and the results of various tests,control group was received recombinant human interferonα-2 b gel,while research group was treated with anti-HPV biological protein dressing.After continuous treatment for 3 menstrual cycles,all the patients were given 9-month follow-up.The results of various tests were recorded,including HPV subtype,cervical thinprep cytology test(TCT),colposcopy and pathological examination.The HPV negative conversion rate of two groups were detected and compared at the end of treatment,after treatment for 3 rd,6 th and 9 th month.The changes of each examinations before treatment and during the last follow-up were compared between the two groups,and the adverse reactions during treatment were recorded.RESULTS Among 100 patients,the main subtypes of HPV were detected,including type 16,type 52 and type 58;no cervical intraepithelial neoplasia(CIN)were observed in more than 90%of cases after TCT examination;most of the cases were chronic cervicitis or low-grade cervical lesions according to colposcopy;and very few parts were CIN gradeⅠaccording to the pathological examination.There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P=0.646).At the end of treatment,the HPV negative conversion rate of research group was 16.00%(8/50),which was not significant from that of control group(P=0.218).After treatment for 3 rd,6 th and 9 th month,the HPV negative conversion rates of the two grou

关 键 词：高危型HPV感染 抗HPV生物蛋白敷料 重组人干扰素Α-2B凝胶 HPV转阴 

分 类 号：R378[医药卫生—病原生物学]