支原体感染盆腔炎患者血清高迁移率族蛋白B1的临床价值  

Clinical value of HMGB1 in patients with pelvic inflammatory disease caused by mycoplasma

作　　者：王丹 涂飞霞 王友珍 陈秀堂 黄小芳 潘一红[2] WANG Dan;TU Fei-xia;WANG You-zhen;CHEN Xiu-tang;HUANG Xiao-fang;PAN Yi-hong(Anji County People's Hospital,Huzhou,Zhejiang 313300,China;不详)

机构地区：[1]安吉县人民医院妇产科,浙江湖州313300 [2]台州市中心医院妇产科,浙江台州318000

出　　处：《中华医院感染学杂志》2020年第3期419-423,共5页Chinese Journal of Nosocomiology

基　　金：浙江省医药卫生一般研究计划基金资助项目(2016KYA194)。

摘　　要：目的探讨支原体感染盆腔炎患者血清高迁移率族蛋白B1(High mobility histone B1,HMGB1)水平及其临床价值。方法选择安吉县人民医院妇产科2016年1月-2017年12月收治的支原体感染盆腔炎患者110例作为盆腔炎组,同期健康体检女性110名作为对照组,盆腔炎组根据感染严重程度分为轻度感染29例,中度感染48例,重度感染33例。测定治疗前后血清HMGB1和C-反应蛋白(CRP)水平。结果盆腔炎组患者治疗前血清HMGB1和CRP分别为(14.36±1.64)μg/L和(12.14±1.03)mg/L高于对照组(P<0.05)。治疗前中度感染患者和重度感染患者血清HMGB1、CRP分别为(14.63±1.57)μg/L、(11.54±1.21)mg/L和(19.54±1.71)μg/L、(16.37±1.12)mg/L高于轻度感染组(P<0.05),重度感染组血清HMGB1和CRP水平高于中度感染组(P<0.05)。盆腔炎患者治疗后血清HMGB1和CRP低于治疗前(P<0.05)。支原体感染盆腔炎患者血清HMGB1和CRP水平呈正相关(r=0.594,P<0.001)。血清HMGB1诊断支原体感染盆腔炎的ROC曲线下面积为0.817,灵敏度为89.54%,特异度为82.13%;血清CRP诊断支原体感染盆腔炎的ROC曲线下面积为0.778,灵敏度为92.14%,特异度为86.25%。结论支原体感染盆腔炎患者血清HMGB1升高,HMGB1水平在支原体感染盆腔炎的诊断、治疗效果及病情严重程度评估中具有重要意义。OBJECTIVE To investigate the serum high mobility histone B1(HMGB1)level and its clinical value in patients with pelvic inflammatory disease caused by mycoplasma.METHODS A total of 110 patients with mycoplasma-infected pelvic inflammatory disease admitted to the Department of Obstetrics and Gynecology,Anji County People’s Hospital from Jan.2016 to Dec.2017 were selected as pelvic inflammatory group,and 110 healthy women were selected as control group.Accorded to the severity of infection,the pelvic inflammatory group patients were divided into 29 cases of mild infection,48 cases of moderate infection and 33 cases of severe infection.The serum HMGB1 and C-reactive protein(CRP)levels were measured before and after treatment.RESULTS The serum HMGB1 and CRP levels of patients in the pelvic inflammatory group were(14.36±1.64)μg/L,(12.14±1.03)mg/L before the treatment,respectively,significantly higher than those in the control group(P<0.05).The serum HMGB1 and CRP levels in the moderately infected group were(14.63±1.57)μg/L and(11.54±1.21)mg/L and the severely infected group were(19.54±1.71)μg/L and(16.37±1.12)mg/L,respectively,significantly higher than those in the mildly infected group(P<0.05).The serum HMGB1 and CRP levels in the severely infected group were significantly higher than those in the moderately infected group(P<0.05).The serum HMGB1 and CRP levels in patients with pelvic inflammatory disease after treatment were significantly lower than before treatment(P<0.05).There was a positive correlation between serum HMGB1 and CRP levels in patients with mycoplasma-infected pelvic inflammatory disease(r=0.594,P<0.001).The area under the ROC curve of serum HMGB1 for diagnosis of mycoplasma infection of pelvic inflammatory disease was 0.817,with the sensitivity of 89.54%and the specificity of 82.13%.The under the ROC curve area of serum CRP for diagnosis of mycoplasma infection of pelvic inflammatory disease was 0.778,with the sensitivity of 92.14%and the specificity of 86.25%,respectively.CONCLUSION The

关 键 词：支原体 盆腔炎 高迁移率族蛋白B1 C-反应蛋白 

分 类 号：R711.33[医药卫生—妇产科学]