头孢呋辛联合阿奇霉素治疗对支原体和衣原体感染孕产妇妊娠结局的影响及安全性分析  

Analysis on the effect and safety of cefuroxime combined with azithromycin on pregnancy outcome of pregnant women with Mycoplasma and Chlamydia infection

作　　者：刘淼[1] 孙琳[2] LIU Miao;SUN Lin(Affiliated Hospital of Jining Medical College,Jining,Shandong 272029,China)

机构地区：[1]济宁医学院附属医院医院感染管理办公室,山东济宁272029 [2]济宁医学院附属医院妇三科,山东济宁272029

出　　处：《中华医院感染学杂志》2020年第3期424-427,共4页Chinese Journal of Nosocomiology

基　　金：山东省卫健委科学研究计划基金资助项目(2016WS0170)。

摘　　要：目的探讨头孢呋辛联合阿奇霉素治疗对支原体和衣原体感染孕产妇妊娠结局的影响及安全性,为治疗孕产妇支原体和衣原体感染及改善感染孕产妇妊娠结局提供依据。方法选择2016年3月-2018年1月于济宁医学院附属医院就诊的妊娠合并支原体和衣原体感染孕妇97例,随机分为研究组50例和对照组47例,对照组给予阿奇霉素治疗,研究组患者在对照组基础上给予头孢呋辛治疗。比较两组治疗临床疗效,治疗期间药物不良反应发生情况及妊娠结局。结果研究组患者疗效优于对照组(P=0.026)。研究组患者药物相关不良反应发生率为12.00%(6/50)低于对照组19.15%(9/47),但差异无统计学意义(P=0.331)。研究组患者早产、胎膜早破、产褥感染、低体质量儿及新生儿窒息不良妊娠结局发生率分别为6.00%、8.00%、4.00%、2.00%和8.00%,总不良妊娠结局28.00%(14/50)低于对照组(P<0.05)。结论头孢呋辛联合阿奇霉素治疗支原体和衣原体感染孕产妇可提高治疗临床疗效,改善孕产妇妊娠结局,而不增加药物相关不良反应,治疗安全性较高,具有一定的临床价值。OBJECTIVE To investigate the effect and safety of cefuroxime combined with azithromycin on pregnancy outcomes of pregnant women with Mycoplasma and Chlamydia infection,so as to provide evidence for the treatment of pregnant women with Mycoplasma and Chlamydia infection and the improvement of pregnancy outcomes of pregnant women with Mycoplasma and Chlamydia infection.METHODS A total of 97 cases of pregnant women with Mycoplasma and Chlamydia infection in the Affiliated Hospital of Jining Medical College from Mar.2016 to Jan.2018 were randomly divided into study group(50 cases)and control group(47 cases).The control group was treated with azithromycin and the observation group was treated with cefuroxime on the basis of the control group.The clinical efficacy,adverse drug reactions and pregnancy outcomes were compared between the two groups.RESULTS The curative effect of the study group was significantly better than that of the control group(P=0.026).The incidence of drug-related adverse reactions in the study group was 12.00%(6/50),lower than that in the control group 19.15%(9/47),but there was no significant difference(P=0.331).Premature delivery,premature rupture of membranes,puerperal infection,low birth weight infants and neonatal asphyxia in the study group were 6.00%,8.00%,4.00%,2.00%and 8.00%the total incidence of adverse pregnancy outcomes was 28.00%(14/50),respectively,significantly lower than those in the control group(P<0.05).CONCLUSION Cefuroxime combined with azithromycin in the treating Mycoplasma and Chlamydia infection of pregnant women could significantly improve the clinical efficacy,improve pregnancy outcomes of pregnant women,without increasing drug-related adverse reactions.The treatment is of high safety and worthy of clinical promotion.

关 键 词：头孢呋辛 阿奇霉素 支原体衣原体 感染 妊娠结局 安全性 

分 类 号：R374[医药卫生—病原生物学]