磷酸奥司他韦联合抗病毒合剂对流感病毒感染患者的临床疗效  

Clinical effect of oseltamivir phosphate combined with antiviral mixture on treatment of patients with influenza virus infection

作　　者：田占红 王晨 郑然 李勇 李世家 TIAN Zhan-hong;WANG Chen;ZHENG Ran;LI Yong;LI Shi-jia(Beijing Huairou Hospital,Beijing 101400,China)

机构地区：[1]北京怀柔医院呼吸科,北京101400 [2]北京怀柔医院中医科,北京101400 [3]北京怀柔医院感染疾病科,北京101400

出　　处：《中华医院感染学杂志》2020年第2期288-291,共4页Chinese Journal of Nosocomiology

基　　金：北京市卫生人才发展计划基金资助项目(292001)。

摘　　要：目的探究磷酸奥司他韦联合抗病毒合剂治疗流感病毒感染的疗效及对患者血清炎症因子水平的影响。方法选取2015年4月-2017年8月在北京怀柔医院就诊的流感病毒感染患者82例为研究对象,采用随机数表法将患者分为联合组和对照组,每组各41例,对照组患者在常规治疗的基础上服用磷酸奥司他韦胶囊,联合组在对照组的基础上联合抗病毒合剂治疗,对比两组患者治疗的有效率,记录两组患者临床症状消失时间及治疗期间出现的不良反应,比较两组患者治疗前后血清炎症因子C-反应蛋白(C-reactive protein,CRP)、白细胞介素-6(interleukin-6,IL-6)和肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平变化。结果联合组患者发热消退、乏力缓解、咳嗽缓解、咽痛缓解时间分别为[(34.69±12.74)h、(60.74±15.54)h、(54.14±23.64)h、(65.49±10.32)h]较对照组明显缩短(P<0.05)。联合组治疗的总有效率为97.56%,高于对照组的78.05%(χ^2=1.840,P=0.021)。两组患者治疗后血清炎症因子CRP、IL-6、TNF-α水平均降低,且联合组改善程度优于对照组(P<0.05)。治疗期间联合组患者未出现与联合用药有关的不良反应。结论应用抗病毒合剂联合磷酸奥司他韦治疗流感病毒感染患者,可有效缓解患者临床症状,减轻炎症反应,加快病情好转,临床效果较好。OBJECTIVE To explore the effect of oseltamivir phosphate combined with antiviral mixture on treatment of patients with influenza virus infection and observe the influence on the serum inflammatory factors. METHODS A total of 82 patients with influenza virus infection who were treated in Beijing Huairou Hospital from Apr 2015 to Aug 2017 were recruited as the study objects and randomly divided into the combination group and the control group, with 41 cases in each group.The control group was treated with oseltamivir phosphate capsules on basis of the conventional therapy, while the combination group was given combined antiviral mixtures on basis of the treatment of the control group.The effective rate of treatment was compared between the two groups of patients, the time of disappearance of clinical symptoms and adverse reactions during treatment were recorded.The levels of serum inflammatory factors C-reactive protein(CRP), interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) were compared between the two groups of patients before and after the treatment. RESULTS The time of fever subsidence, time of fatigue relief, time of cough relief and time of pharyngalgia relief of the combination group were respectively(34.69±12.74)h,(60.74±15.54)h,(54.14±23.64)h and(65.49±10.32)h, significantly shorter than those of the control group(P<0.05).The total effective rate of treatment of the combination group was 97.56%, significantly higher than 78.05% of the control group(χ^2=1.840,P=0.021).The levels of serum inflammatory factors CRP, IL-6 and TNF-α of the two groups of patients declined after the treatment, and the above indexes were improved better in the combination group than in the control group(P<0.05).The patients of the combination group did not have any adverse reactions that were related to the combined use of antibiotics. CONCLUSION Oseltamivir phosphate combined with antiviral mixture can effectively relieve the clinical symptoms of the patients with influenza virus infection, alleviate the inflammatory

关 键 词：奥司他韦 抗病毒合剂 流行性感冒 上呼吸道感染 

分 类 号：R511.7[医药卫生—内科学]