快速突变Y-STRs分子标记的法医遗传学研究进展  

Progress of rapidly-mutating Y-STRs in forensic genetics

作　　者：郭利伟 王克杰 黄艳梅 Guo Liwei;Wang Kejie;Huang Yanmei(Department of Forensic Genetics,School of Forensic Medicine,Xinxiang Medical University,Xinxiang 453003,China;Xinxiang Key Laboratory of Forensic Science Evidence,Xinxiang 453003,China)

机构地区：[1]新乡医学院法医学院法医物证学教研室,河南新乡453003 [2]新乡市法庭科学证据重点实验室,河南新乡453003

出　　处：《中国法医学杂志》2020年第1期51-55,59,共6页Chinese Journal of Forensic Medicine

基　　金：河南省科技攻关项目(182102310240);河南省高等学校重点科研项目(16B310006)。

摘　　要：Y染色体短串联重复序列在性犯罪案件及父系亲缘关系鉴定中具有特殊的应用价值,但是,采用常规标准的Y-STRs尚不能区分同一父系来源的男性个体。13个快速突变Y-STRs被证明可以相对提高男性谱系分化的分辨率和同一父系男性个体的相对分离,拓展了Y-STRs在法庭科学领域的应用范围和价值。Y-chromosomal short tandem repeat(Y-STR)loci has been widely used in forensic case work especially in sexual assault cases and paternity testing of male offspring.However,Y-STRs widely used in forensics have low haplotype diversity in some populations and cannot discriminate between individuals from the same paternal linage.13 rapidlymutating Y-STRs(RM Y-STRs)have been shown to be able to better differentiate between close males belonging to the same paternal lineage and separate males in the same paternal family due to their high mutation rates.thus greatly expanding the application scope and value of RM Y-STRs in forensic science.

关 键 词：法医遗传学 Y-STRS 快速突变 个体识别 

分 类 号：DF795.1[医药卫生—法医学]